葛根-红景天口服液对四氯化碳诱发急性肝损伤的保护作用  

The protective effect of Gegeng-Hongjingtian to acute chemical hepatic injury induced by carbon tetrachloride on mice

作　　者：潘京一[1] 杨隽[1] 潘喜华[1] 郑勇英[1] 叶于薇[1] 董妙珠[1] 仲伟鉴[1] 

机构地区：[1]上海市疾病预防控制中心,上海200336

出　　处：《上海预防医学》2004年第5期206-208,共3页Shanghai Journal of Preventive Medicine

摘　　要：[目的 ]　观察葛根—红景天口服液对小白鼠脂质过氧化和转氨酶活性的影响以及肝脏病理学变化 ,并探讨其可能机制。　 [方法 ]　以四氯化碳 (CCl4)染毒小白鼠为肝损伤动物模型 ,按“保健食品功能学评价程序和检验方法”检测。　 [结果 ]　与四氯化碳模型组比较 ,葛根 -红景天中、高剂量组均可明显降低血清谷草转氨酶 (ALT)、血清谷丙转氨酶 (AST)活性和三酰甘油 (TG)、肝丙二醛 (MDA)含量 ;升高还原型谷胱甘肽 (GSH )含量。葛根 -红景天中、高剂量组可改善肝细胞退行性变 ,且高剂量组可明显减轻四氯化碳引起的肝细胞坏死。　 [结论 ]　葛根 -红景天口服液具有明显减轻由四氯化碳所致的肝脂质过氧化损害的作用 。Objective] To observe the effects of Gegeng-Hongjingtian on Lipid peroxidation and transaminase and pathological changes of liver in mice and to explore the possible mechanism. [Methods] Carbon tetrachloride(CCl 4) was used as a liver injury toxicant. Tests were done in accordance with “Programs and Methods of Health Food Function Evaluation' issued by the Ministry of health. [Results] Compared with the hepatic injury model of the control group, the activities of liver ALT and AST of exposure to medium and high dosage of Gegeng-Hongjingtian groups were significantly decreased and the TG and liver MDA content also decreased while liver GSH level increased. Furthermore, hepatocyte degeneration exposure to medium and high dosage of Gegeng-Hongjingtian groups was ameliorated and hepatocyte necrosis of the highest dosage group was relieved [Conclusion] The Gegeng-Hongjingtian juice could have obvious defensive effect on the liver LPO injury in mice induced by CCl 4, which may be associated with the ability of Gegeng-Hongjingtian juice in removing the free radical.

关 键 词：葛根-红景天口服液 四氯化碳 急性肝损伤 自由基 脂质过氧化 

分 类 号：R285[医药卫生—中药学]