环氧化酶-2的表达与胃癌浸润转移的关系  

Correlation between expression of cyclooxygenase-2 and invasiveness and metastasis in gastric carcinoma

作　　者：李红霞[1] 苌新明[1] 闫利华[2] 和水祥[1] 

机构地区：[1]西安交通大学第一医院消化内科,陕西西安710061 [2]榆林市北方医院,陕西榆林719000

出　　处：《实用肿瘤杂志》2004年第3期210-212,共3页Journal of Practical Oncology

摘　　要：目的　探讨环氧化酶 - 2 (cyclooxygenase- 2 ,COX- 2 )在胃癌组织中的表达与胃癌浸润转移的关系。方法　采用免疫组化 S- P法检测 4 5例胃癌手术切除标本 COX- 2的阳性表达。结果　胃癌组织 COX- 2的阳性表达率(77.8% )明显高于癌旁组织 (33.3% ,P<0 .0 1)。有局部淋巴结转移者 COX- 2的阳性表达率明显高于无转移者 (分别为 86 .1%和 4 4 .4 % ,P<0 .0 5 ) ;浸润达浆膜层者明显高于未达浆膜层者 (分别为 87.9%和 5 0 .0 % ,P<0 .0 5 ) ; 、 期胃癌组织明显高于 、 期 (分别为 90 .9%和 4 1.7% ,P<0 .0 5 )。结论　 COX- 2与胃癌的发生有关 ,COX-Objective To evaluate the expression of cyclooxygenase-2(COX-2) in gastric carcinoma and its relationship with invasion and metastasis of the disease.Methods Immunohistochemical stain was used for detecting the expression of COX-2 in 45 resected specimens of gastric carcinoma. Paracancerous tissues were examined as control. Results The rate of COX-2 expression in gastric cancers was significantly increased compared with that in paracancerous tissues (77.8%,33.3%,P<0.01).In 36 gastric carcinoma specimens with lymph node metastasis, the rate of COX-2 expression was higher than that in the specimens without metastasis(86.1%, 44.4%,P<0.05).The rate of COX-2 expression in the specimens with invaded serosa was significantly higher than that without invaded serosa(87.9%,50.0%,P<0.05).The rate of COX-2 expression in cancers of stage Ⅲ and Ⅳ was significantly higher than that in stage Ⅰ and Ⅱ.Conclusion These data indicate that the rate of COX-2 expression is well correlated with lymph-node metastasis, depth of invasion and TNM stages.

关 键 词：胃肿瘤 前列腺素内过氧化物合酶 肿瘤转移 免疫组织化学 

分 类 号：R735.2[医药卫生—肿瘤]