金黄色葡萄球菌DNA体内抗肿瘤研究  

Experimental Study on Anti-tumor Immunity with Chromatic DNA from Staphylococcus Aureus in Vivo

作　　者：历风元[1] 吴鄂生[1] 胡成平[1] 杨红忠[1] 张卿[1] 欧阳取长[1] 

机构地区：[1]中南大学湘雅医院呼吸内科,湖南长沙410008

出　　处：《中国医师杂志》2004年第6期754-756,共3页Journal of Chinese Physician

摘　　要：目的　探讨金黄色葡萄球菌染色体DNA(S .aureusDNA)体内抗肿瘤免疫的效果及其免疫机制。方法　纯化提取金黄色葡萄球菌染色体DNA进行抗肿瘤及免疫学指标的测定。结果　S .aureusDNA腹腔注射给药可抑制肿瘤生长 ,提高荷瘤裸鼠血清内IFN -γ含量 ,调节其TNF -α的水平。结论　S .aureusDNA具有抗肿瘤免疫特性 ,为微生物DNA制剂开发应用于抗肿瘤治疗提供了科学依据。Objective To investigate the effects of staphylococcus aureus (S.aureus) DNA on anti-tumor in vivo and its mechanism. Methods The chromatic DNA purified from S.aureus was used in the experiments of antitumor in vivo, and immunological indices were measured. Results S.aureus DNA could inhibit the tumor growth by peritoneal injection, increase the serum IFN-γ level and regulate the serum TNF-α level in the nude mice carrying transplant tumor. Conclusion S aureus DNA has a characteristic of anti-tumor immunity, and can be used in immunotherapeutic treatment of tumors.

关 键 词：金黄色葡萄球菌 DNA 抗肿瘤作用 免疫治疗 

分 类 号：R73-36[医药卫生—肿瘤]