硒化亚油酸及硒化亚麻酸对肿瘤细胞DNA合成的影响  

THE EFFECT OF TWO KINDS OF NEW ANTITUMOR AGENTS ON THE DNA SYNTHESIS OF TUMOR CELLS

作　　者：王仲会 薛少安 齐浩 薛永泉 陶静仪[3] 

机构地区：[1]陕西师范大学生物系,西安710062 [2]陕西师范大学化学系,西安710062 [3]第四军医大学药理教研室,西安710033

出　　处：《癌症》1993年第5期402-403,418,共3页Chinese Journal of Cancer

摘　　要：本文报道用氚一胸腺嘧啶核苷（＾３Ｈ－ＴｄＲ）掺入法研究了新型抗癌药－硒化亚油酸及硒化亚麻酸对小鼠Ｓ１８０细胞ＤＮＡ合成的影响。结果表明，这两种新型抗肿瘤药物能明显抑制＾３Ｈ－ＴｄＲ掺入肿瘤细胞，在１００μｇ／ｍｌ的浓度下，它们对Ｓ１８０瘤细胞ＤＮＡ合成的抑制率分别达到８９．０％和８８．３％，这些结果表明硒化亚油酸及硒化亚麻酸的抗癌机理之一是它们对＾３Ｈ－ＴｄＲ掺入肿瘤细胞的干扰。The effect of two kinds of new antitumor agents( linoleic acid containing selenium and linolenic acid containing selenium) on the DNA synthesis of Siso tumor cells in vitro were investigated with method of 3H- TdR incorporation. The results showed that these two kinds of new agents can obviously inhibit the incorporation of 3H-TdR into S180tumor cells. At the concentration of 100 ug/ ml, their inhibition retes were 89.0% for lenoleic acid containing selenium and 88 .3% for linolenic acid containing selenium .These results indicated that the possible antitumor mechanism of these two agents is that they can inhibit the incorporation of 3H-TdR into tumor cells and hence inhibit the DNA synthesis of the tumor cells.

关 键 词：硒化亚油酸 硒化亚麻酸 肿瘤细胞 

分 类 号：R730.21[医药卫生—肿瘤]