肾癌组织PDGFR及c-Fos的表达研究  

A study on the expressions of PDGFR and c-Fos protein in human renal cell carcinoma

作　　者：姚华强[1] 彭瑛 李学得[3] 钟世镇[1] 何恢绪[4] 李忠华[1] 

机构地区：[1]第一军医大学临床解剖研究所,广东510515 [2]广州军区后勤部东皋干休所 [3]桂林解放军181医院 [4]广州军区总医院泌尿外科

出　　处：《肿瘤》2004年第3期261-263,共3页Tumor

基　　金：广东省科技计划项目 (编号 :A3 0 2 0 2 0 40 1)

摘　　要：目的　探讨PDGFR及蛋白c Fos的表达与肾细胞癌 (RCC)发生的关系。方法　应用免疫组化SP法检测 12例正常肾组织、14例癌旁肾组织、4 6例肾细胞癌组织中PDGFR和c Fos蛋白的表达 ,并结合肾癌的分级、分期和随访结果进行分析。结果　PDGFR及c Fos在RCC组织中的表达阳性率分别为 73.91%及 5 2 .17% ,明显高于正常组织及癌旁组织 ,有显著性差异。PDGFR在透明细胞癌中的表达阳性率明显高于颗粒细胞癌 ,有显著性差异。PDGFR及c Fos在RCC组织血管中的表达明显增强。PDGFR的表达与RCC的分级相关。结论　PDGFR及c Fos的过度表达与RCC的发生密切相关 ,并与肿瘤血管形成相关。PDGFR的表达与RCC的恶性程度相关。Objective To elucidate the relationships between the expressions of c Fos, platelet derived growth factor receptor (PDGFR) and human renal cell carcinoma. Methods The expressions of PDGFR and c Fos protein were investigated in 12 normal renal tissues, 14 adjacent non carcinoma tissues and 46 human renal cell carcinoma tissues using SP immunohistochemical technique. Results PDGFR expressed in 73.91% of the carcinoma tissues, and c Fos protein 52.17%. Both expressions were significantly higher than that in normal and adjacent non carcinoma tissues ( P <0.01). Conclusion The expressions of PDGFR and c Fos protein might involve in the development of human renal carcinoma. No correlations between both expressions of PDGFR. c Fos protein and tumor grade, stage has been observed. There is also no relationship between the expression of PDGFR and c Fos.

关 键 词：血小板衍化生长因子 原癌基因 C-FOS蛋白 肾癌 免疫组化SP法 血管生成 

分 类 号：R737.11[医药卫生—肿瘤]