全反式维甲酸治疗急性早幼粒细胞白血病20例临床疗效观察  

Clinical Obersevation on Effects of All-trans Retionoic Acid in 20 Patients With Acute Promyelocytic Leudemia

作　　者：潘理明[1] 孙自敏[1] 胡平[1] 朱微波[1] 徐华梅[2] 吴竞生 王祖贻[2] 

机构地区：[1]安徽省立医院血液科 [2]安徽省立医院血研室

出　　处：《安徽医科大学学报》1993年第1期42-44,共3页Acta Universitatis Medicinalis Anhui

摘　　要：单用全反式维甲酸(RA)诱导治疗急性早幼粒细胞白血病(APL)20例,完全缓解率达90%,诱导天数短(中位数为32d)。治疗过程中未发生DIC,亦无因强烈化疗引起骨髓抑制后造成的感染和出血的危险。该药的副反应轻,患者均能耐受。该组的中位生存期已达630d,可望长期存活。Twenty patients with APL were treated with all-trans rectinoic acid (RA). The complete remission (CR) rate was 90% and the median of induction time was 32d. None of the cases developed disseminated intravascular coagulation and bone marrow inhibition during the treatment. There was no significant side effect except dryness of skin and mouth. The medium survival time was 630 d. The reults showed that all-trans RA was a very effective medicine to remit acute promyelocytic leukemia.

关 键 词：白血病 维甲酸 

分 类 号：R733.710.5[医药卫生—肿瘤]