噪声引起神经元动力学特征的改变  

Noise-induced changes of dynamic characteristics of neurons

作　　者：文治洪[1] 胡三觉[1] 董秀珍[2] 朱俊玲[1] 菅忠[1] 邢俊玲[1] 

机构地区：[1]第四军医大学全军神经生物研究所,陕西西安710033 [2]第四军医大学生物医学工程系医电教研室,陕西西安710033

出　　处：《第四军医大学学报》2004年第10期948-949,共2页Journal of the Fourth Military Medical University

基　　金：国家自然科学基金资助项目 (G30 0 30 0 4 0 ;G30 2 0 0 0 84) ;国家重点基础规划脑功能和脑重大疾病的基础研究 (G1 9990 540 0 0 )

摘　　要：目的 :研究噪声对阈下膜电位振荡和神经元放电的影响 .方法 :在神经元的HH(Hodgkin Huxleymodel,HH)计算机模型上 ,采用不同频率的正弦波波形刺激 ,观察神经元的膜电位变化 ;观察神经元阈下膜电位振荡和放电在不同噪声强度下的变化 .结果 :神经元的膜电位在不同的频率刺激时不同 ,在低频和高频时小 ,在中间一段频率刺激时明显变大 .在噪声刺激的影响下 ,阈下膜电位振荡的发生时间明显提前 ,并且阈下膜电位振荡的幅度显著增加 .结论 :神经元存在共振特性 ,对某一频率范围的刺激有更强的响应 ;噪声可以降低阈下膜电位振荡发生的膜电位水平 ,有利于神经元产生阈下膜电位振荡和放电 。AIM: To study the effects of noise on the subthreshold membrane potential oscillation (SMPO) and firing of neurons. METHODS: Changes of membrane potential induced by sine wave stimulus of different frequency was measured on Hodgkin Huxley (HH) computer model and SMOP and firing induced by noise of different intensity were also measured. RESULTS: The membrane potential induced by sine wave stimulus of different frequency was different, lower at lower and higher frequencies and higher at middle frequency range. With increased noise stimulus, the initial time of oscillation generation occurred earlier and the amplitude of oscillation increased. CONCLUSION: There is a range of frequency where the membrane potential response of neurons is stronger. Noise reduces the level of membrane potential of generating oscillation and firing. Noise helps neuron to generate oscillation and firing, thus improving the sensitivity of neurons.

关 键 词：噪声 膜电位 神经元 

分 类 号：R743[医药卫生—神经病学与精神病学]