恶性肿瘤患者外周淋巴细胞膜β_2-M表达的观察  

OBSERVATION ON THE EXPRESSION OF β_2-MICROGLOBULIN ON MEMBRANES OF PERIPHERAL LYMPHOCYTES FROM THE PATIENTS WITH MALIGNANT TUMOR

作　　者：赵明敏[1] 葛敏[1] 王洛夫[2] 陶荣亚[3] 

机构地区：[1]蚌埠医学院药理学教研室 [2]蚌埠医学院核医学教研室 [3]蚌埠医学院附院血液病科

出　　处：《蚌埠医学院学报》1993年第2期75-77,共3页Journal of Bengbu Medical College

摘　　要：本文报道健康成人及恶性肿瘤患者外周淋巴细胞膜和血清β_2-M的放免分析结果。健康成人淋巴细胞膜和血清β_2-M测定值分别为2.1±0.35μg/10~6细胞(n=23)和2.06±0.31μg/ml(n=40)。46例恶性肿瘤中有93.5％患者外周淋巴细胞膜β_2-M量极显著降低(P<0.001)。38例消化系统恶性肿瘤和7例淋巴瘤患者血清β_2-M量呈极显著性增高(P<0.001),两者阳性率分别为76％和87.5％。结果表明肿瘤患者外周淋巴细胞膜表达的β_2-M量与血清β_2-M水平增高不呈平行关系,似与外周淋巴细胞的调节代谢无关。提示血清β_2-M水平升高,可能由于代谢活跃的肿瘤细胞释放β_2-M增加所致。本文46例肿瘤患者中有93.5％外周淋巴细胞膜β_2-M量显著降低,表明与患者体内淋巴细胞膜β_2-M合成能力和细胞免疫活性降低相关;也间接揭示淋巴细胞膜β_2-M基因表达的调节功能受到抑制或障碍。文中还讨论了影响淋巴细胞膜β_2-M基因调节的因素。This report describes a radioimmunoassay for the quantitation of β2-Microglobulin (β-M) on lymphocyte membranes and in serum from the patients with malignant tumor and healthy subjects. The value of β2-M on lymphocyte membranes and in serum determined by a radioimmunoassay in -10 normal subjects was 2. 1 8±0. 35μg/l 06 cell(n = 23) and 2. 06±0. 31 μg/ml respectively. The content of β2-M on lymphocyte membranes decreased significantly( P <0. 001) in 93. 5% of 46 patients with malignant tumor. But the serum β2-M increased significantly in 38 alimentary systemic malignant tumors and 7 lymphomas,both their positive rate was 76% and 87. 5%,respectively. This result is in agreement with those reports by other authors,suggesting that the absence of parallel relationship between the increase in serum β2-M and the expression of β2-M on lymphocyte membranes from the patients with malignant tumor. It seems there is no correlation with the regulation and metabolism of peripheral lymphocytes,which may be due to the release increased by the tumor cells,so that the serum β2-M significantly increased. This study showed the β2-M on lymphocyte membranes was decreased significantly in 93. 5% of 46 patients with malignant tumor,these data showed in close relation to the decrease of synthetic function of β2-M on lymphocyte membranes and cellular immune activity .They also indirectly revealed an abnormality or inhibited in the regulation of gene expression of β2-M on lymphocyte membranes. In this report,we discuss the effects of some factors on the regulation of the β2-M gene.

关 键 词：淋巴细胞 癌 Β2微球蛋白 血清 

分 类 号：R730.2[医药卫生—肿瘤]