上皮钙粘附素/连环素复合体在上皮性卵巢肿瘤中的表达及临床意义  

Expression of E-cadherin/catenin complex and its clinical significance in epithelial ovarian tumors

作　　者：刘鸣[1] 汤春生[1] 张水红[2] 穆玉兰[1] 马金龙[1] 

机构地区：[1]山东省立医院,济南250021 [2]山东大学第二医院

出　　处：《现代妇产科进展》2004年第3期181-183,共3页Progress in Obstetrics and Gynecology

基　　金：山东省优秀中青年科学家科研奖励基金资助项目 (0 1BS5 6 )

摘　　要：目的 :探讨上皮钙粘附素 /连环素 (E cd/cat)复合体在上皮性卵巢肿瘤中的表达及意义。方法 :应用免疫组化SABC法检测 87例上皮性卵巢肿瘤中E cd、α 、β 、γ cat蛋白的表达情况。结果 :上皮性卵巢癌 (EOC)中E cd、α 、β 、γ cat的表达较卵巢交界性肿瘤及良性肿瘤明显减少 ;17例转移灶中各指标的表达较原发灶降低 ,但无统计学差异 ;E cd和各连环素的表达缺失或减少均与EOC的病理分级显著相关 ,但与临床分期无关 ;γ cat表达缺失或减少与腹水形成、腹腔广泛转移显著相关 ;联合检测复合体 ,部分或全部指标表达异常与临床分期、组织分化、有无腹水及腹腔广泛转移显著相关。结论 :E cd/cat复合体的表达异常与EOC的发生发展及转移密切相关 ,联合检测较单纯检测E cd更有助于评价EOC的生物学行为。Objective:To study the expressions of E-cadherin (E-cd), α-, β-, γ-catenin (cat) and their significance in epithelial ovarian tumors. Method:Immunohistochemistry (SABC mehthod) was used to detect the expressions of E-cd,α-cat,β-cat and γ-cat in 87 cases of epithelial ovarian tumors.Results:The expressions of E-cad,α-cat,β-cat,and γ-cat in EOC were significantly lower than those in benign tumors and borderline tumors.The expressions of the complex in 17 metastatic lesions were lower than those in their primary lesions, but there were no significant difference.The expressions of E-cad,α-cat,β-cat and γ-cat were correlated with pathologic grade,but not with clinical stage. Abnormal expression of γ-cat was correlated with ascite, seeding metastasis. Abnormal expression of the whole complex was correlated with clinical stage, pathologic grade,ascite and seeding metastasis.Conclusion:The abnormal expression of E-cd/cat complex is correlated with the progress and metastasis of EOC, and it is beneficial for evaluating the cell biological behavior of EOC than detecting E-cd or catenins alone.

关 键 词：卵巢肿瘤 上皮钙粘附素 连环素 免疫组织化学 

分 类 号：R737.31[医药卫生—肿瘤]