动物抗冷性的基因表达机制  

The Gene Expression Mechanism of Cold Resistance in Animals

作　　者：李跃强[1] 盛承发[1] 

机构地区：[1]中国科学院动物研究所,北京100080

出　　处：《动物学杂志》2004年第3期97-102,共6页Chinese Journal of Zoology

基　　金：中国科学院知识创新工程领域前沿项目 (KSCX3 IOZ 0 4 ) ;国家自然科学基金优秀中青年人才专项基金 (No.392 2 1 0 0 1 )资助

摘　　要：简要综述了包括抗冻蛋白作用机理在内的动物抗冷性的基因表达调节机制。通过在寒冷逆境下转录抗冻蛋白、纤维蛋白原等耐冻性相关蛋白基因 ,形成mRNA ,然后在各种转录翻译调节因子的调节下表达形成蛋白质和酶 ,从而形成冰冻耐性或冰冻避性或毁损修复反应。其中 ,转录后调节和上调节是动物常用的抗冷基因表达机制。The gene expression mechanisms of cold resistance in animals including the functional mechanism of antifreeze proteins are summarized in this paper. Under the adverse circumstance of cold, the genes of antifreeze protein, fibrinogen and other cold-related proteins are transcribed into mRNA and then, translated into proteins or enzymes under the regulation of translational modulators. The post-transcriptional regulations and up-regulations are most important for the establishment of cold resistance. Small organic molecules have prominent cooperative effects in the enhancement of animal cold resistance. The cold resistance genes are one type of growth redundancy.

关 键 词：抗冻蛋白 基因 上调节 小分子 

分 类 号：Q786[生物学—分子生物学]