蛋白激酶在双歧杆菌预防大肠癌中的作用  

Effect of bifidobacterium on the prevention from large bowel carcinoma

作　　者：孔欣[1] 王立生 

机构地区：[1]深圳大学医院,广东深圳518060 [2]深圳市福田人民医院消化科

出　　处：《中国校医》2004年第3期205-207,共3页Chinese Journal of School Doctor

摘　　要：目的　从信号传导这一层次探索双歧杆菌预防大肠癌生长的机理。　方法　以大肠癌裸鼠移植瘤为运动模型 ,预先用青春型双歧杆菌注射于裸鼠腹腔 ,然后以激光共聚焦显微镜检测大肠癌移植瘤组织MAPK家系中的ERK1/ 2、JNK和p38的含量。　结果　双歧杆菌预防组大肠癌组织EPK1/ 2的平均荧光强度明显低于肿瘤对照组 (P <0 .0 1) ,而JNK和p38的平均荧光强度在两组间差异则无显著意义 (P >0 .0 5 )。　结论　青春型双歧杆菌通过抑制ERK1/ 2的活化来预防大肠癌的生长。Objective To investigate the mechanisms of bifidobacteria to prevent the growth of lager bowel carcinoma in view of signal transduction. Methods The animal model of large bowel carcinoma nude mouse transplantation tumores was set up.Bifidobacteria adolescence were intraperitoneally injected into nude mice in advance.The content of ERK1/2?JNK and p38 of MAPK family in large bowel carcinoma transplantation tumor tissues was detected by using laser scanning confocal microscopy. Results The average fluorescent strength of ERK1/2 of large bowel carcinoma tissues in bifidobacterium prevention tissues was significantly lower when compared with the tumor control group(P<0.01).The average fluorescent strength of JNK and p38 was no difference in the two groups(P>0.05). Conclusion Bifidobacteria adolescene could prevent the growth of large bowel carcinoma through inhibing the ERK1/2 activation.

关 键 词：蛋白激酶 双歧杆菌 预防措施 大肠癌 肿瘤 

分 类 号：R735.34[医药卫生—肿瘤] R378[医药卫生—临床医学]