反应停联合地塞米松治疗多发性骨髓瘤临床观察  

Therapeutic effectiveness of thalidomide and dexamethasone to multiple myeloma and its side effects

作　　者：朱世论[1] 孙致信[1] 

机构地区：[1]上海市长宁区中心医院血液科,上海200336

出　　处：《海南医学》2004年第7期30-31,共2页Hainan Medical Journal

摘　　要：目的　观察反应停治疗多发性骨髓瘤 (multiplemyelomaMM)的疗效及不良反应。方法　反应停剂量为15 0 -4 0 0mg d ,地塞米松 2 0 -4 0mg d ,d1-4 ,d9-12 ,d17-2 0。根据M蛋白及骨髓中骨髓瘤细胞的减少情况来判断疗效 ,同时观察血象、肾功能、X线等变化。结果　反应停联合糖皮质激素治疗 9例患者 4例部分缓解 ,2例进步 ,2例无效。总有效率达 66.7%,其中 ,难治性MM有效率达 60 .0 %。大多数患者有轻中度副反应 ,一般能耐受 ,外周血三系大多数无明显下降。Objective To observe the therapeutic effectiveness and side effects of thalidomide to multiple myeloma. Methods The dosage of thalidomide was 150-400mg/d,dexamethasone was 20-40 mg/d,dl-4,d9-12,d17-20.The therapeutic effectiveness is classified into partial remission,improvement and uneffective, according to the decrease of serum M protein and bone marrow myeloma cells.Peripheral blood counts,renal function and X-rays were also observed.Results The total effective rate was 66.7%. There were no serious side effects.Conclusions Therapy of thalidomide and dexamethasone to multiple myeloma was effective methods and there were no serious side effects.

关 键 词：反应停 糖皮质激素 多发性骨髓瘤 

分 类 号：R733.3[医药卫生—肿瘤]