乙氧苯柳胺的合成工艺改进  

Modification of the synthetic process of etofesalamide

作　　者：姚建文[1] 刘翔[2] 

机构地区：[1]烟台大学药学院,山东烟台264005 [2]沈阳市第六人民医院,辽宁沈阳110006

出　　处：《中国药物化学杂志》2004年第3期176-177,共2页Chinese Journal of Medicinal Chemistry

摘　　要：水杨酸与碳酸钠在氯苯中反应得到水杨酸钠 ,然后在三氯化磷存在下与对乙氧基苯胺直接缩合制备乙氧苯柳胺。产品总收率由文献报道的 4 2 6 %提高到 86 7% ,新工艺反应步骤简单 ,生产成本低 。To improve the synthetic technology of etofesalamide(NSAIDs),salicylic acid reacted with sodium carbonate using chlorobenzene as a solvent to give sodium salicylate (2),2 condensed with p-ethoxyaniline using phosphorous trichloride as a condensation agent to give etofesalamide.This new process has the features of a simple process,lower cost and higher yield and the overall yield of etofesalamide has been increased from 42.6% to 86.7%.The structure of the title compound was confirmed by IR,~1H-NMR and MS.

关 键 词：药物化学 工艺研究 乙氧苯柳胺 水杨酸 对乙氧基苯胺 

分 类 号：TQ463[化学工程—制药化工]