N-二异丙氧磷酰化氨基酸的合成  

Synthesis of N-(Diisopropyloxyphosphoryl)amino Acids

作　　者：赵玉芬[1] 张建臣[2] 曹书霞[2] 徐军[2] 荣垂林[2] 屈凌波[2] 

机构地区：[1]清华大学生命有机磷化学与化学生物学教育部重点实验室,北京100084 [2]郑州大学化学系化学生物学重点实验室,郑州450052

出　　处：《有机化学》2004年第6期609-615,共7页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金 (No.2 0 1 32 0 2 0 )资助项目

摘　　要：以亚磷酸二异丙酯为磷酰化试剂、次氯酸钠为氯代试剂首次对 2 0种常见的α 氨基酸进行了磷酰化 .通过添加适量四丁基溴化铵为相转移催化剂 ,使用过量的亚磷酸二异丙酯以补偿其在强碱环境中的水解 ,从而提高了反应产率 .所得产物经核磁共振谱。In this paper twenty kinds of N- ( diisopropyloxyphosphoryl) amino acids were first synthesized using diisopropyl phosphite as the phosphorylating agent, and sodium hypochlorite as the chlorinating agent. The yield was increased through adding tetrabutyl. ammonium bromide as the phase transfer catalyst, and using excessive diisopropyl phosphite to compensate its hydrolyzation. The products were identified by NMR, IR and MS spectra, and their spectral characterizations were analyzed and summarized.

关 键 词：N-二异丙氧磷酰化氨基酸 合成 Α-氨基酸 磷酰化 相转移催化剂 

分 类 号：O627[理学—有机化学]