新型化学杂交剂哒嗪酮衍生物的合成及其对小麦去雄活性研究  

Synthesis and Hybridizing Activity of Novel Chemical Hybridizing Agent Pyridazinone Derivatives

作　　者：齐传民[1] 陈万义[2] 杨凌春[1] 蒋明亮[2] 

机构地区：[1]北京师范大学化学系,北京100875 [2]中国农业大学应用化学研究所,北京100094

出　　处：《有机化学》2004年第6期645-649,共5页Chinese Journal of Organic Chemistry

基　　金：国家自然科学基金 (No.2 980 2 0 0 1 );博士后基金资助项目

摘　　要：从吡喃酮与不同的芳基重氮盐的偶联反应制备了 1,4 二氢 3 羧基哒嗪 4 酮类化合物 ,并首次以它们为原料分别与氨基硫脲和肼或苯肼进行环合反应得到了两类去雄化学杂交剂杂环化合物———哒嗪酮氨基噻唑以及哒嗪吡唑酮化合物 .初步去雄活性实验显示哒嗪酮氨基噻唑盐酸盐类化合物在较高剂量时具有去雄活性 ,在剂量为 2 10 0g/ha时去雄率达 99%左右 .A series of novel latent chemical hybridizing agent pyridazinone derivatives were synthesized from 1,4 dihydro 3 carboxyl pyridazin 4 one compounds and aminothiourea, hydrazine, phenylhydrazine respectively by cyclization, where 1,4 dihydro 3 carboxyl pyridazin 4 one compounds were obtained from the various arylamine diazonium salt and pyronone by coupling reaction. It is the first time to obtain five pyridazin 4 on 3 yl aminothiazole and five pyrazolono[3,4 c ]pyridazine derivatives. Furthermore, the derivatives can be used as latent chemical hybridizing agents, which has been confirmed and discussed here. In large doses, pyridazin 4 on 3 yl aminothiazole hydrochloride salts had hybridizing activity and percent sterility of them was 99% in 2100 g/ha.

关 键 词：化学杂交剂 哒嗪酮衍生物 合成 去雄活性 剂量 吡喃酮 芳基重氮盐 

分 类 号：TQ452[化学工程—农药化工]