Survivin,Bcl-2在乳腺癌中的表达及意义  

EXPRESSION OF SURVIVIN AND Bcl-2 IN BREAST CARCINOMA AND THEIR SIGNIFICANCE

作　　者：谢平[1] 阮秋蓉[1] 李军川[2] 

机构地区：[1]华中科技大学同济医学院病理学系,武汉430030 [2]湖北省荆州市第一人民医院病理科,湖北434000

出　　处：《中国组织化学与细胞化学杂志》2004年第2期147-151,共5页Chinese Journal of Histochemistry and Cytochemistry

摘　　要：目的　探讨Survivin ,Bcl 2在乳腺癌中的表达及其与细胞凋亡和增殖的关系。方法　用免疫组化S P法检测 6 0例乳腺癌中的Survivin ,Bcl 2 ,PCNA的表达。并用TUNEL法测定凋亡指数。结果　Survivin与病人的年龄、肿瘤的大小、组织学分级、淋巴结的转移无关 ,但与病人的生存期限有关 ;Bcl 2与乳腺癌组织学分级有关。Survivin与细胞的凋亡和增殖有关 ;Bcl 2只与细胞的凋亡有关。结论　Survivin与乳腺癌病人的生存期有关 ,可作为独立的预后因素 ;Survivin表达与Bcl 2表达之间无相关性 ,它们是通过不同途径发挥各自的生物学作用。? Objective To research the expression of Survivin and Bcl-2 in breast carcinoma. Method The expression of Survivin, Bcl-2 and PCNA in 60 cases of breast carcinoma was detected by using S-P immunohistochemical method. Meanwhile, apoptosis was demonstrated by TUNEL method. Result Survivin expression was independent of the patient's age, tumor size, histological grade and nodal status, but it had a relationship with the patient's survival. The expression of Bcl-2 had only a relationship with the histological grade. Survivinexpression had a relationship with the apoptosis and proliferation of breast cancer while Bcl-2 expression was only related to apoptosis. Conclusion Survivin is an independent prognostic indicator of prognosis. There is no relationship between the expression of Survivin and that of Bcl-2. They exert their effect in different ways.

关 键 词：乳腺癌 免疫组织化学 TUNEL法 凋亡指数 SURVIVIN 

分 类 号：R737.9[医药卫生—肿瘤] R392.31[医药卫生—临床医学]