PTEN蛋白表达和明胶酶及其抑制因子在乳腺癌侵袭转移中的关系  

RELATIONSHIP BETWEEN PTEN EXPRESSION AND GELATINASES AND THEIR INHIBITOR IN INVASION AND METASTASIS OF BREAST CANCER

作　　者：吴正升[1] 吴强[1] 周隽[1] 杨枫[1] 

机构地区：[1]安徽医科大学病理学教研室,合肥230032

出　　处：《中国组织化学与细胞化学杂志》2004年第2期193-198,共6页Chinese Journal of Histochemistry and Cytochemistry

基　　金：安徽省卫生厅医学科学研究基金资助 (2 0 0 2 A 0 2 9)

摘　　要：目的　研究乳腺癌中明胶酶 (MMP 2、MMP 9)及其抑制物 (TIMP 1)与抑癌基因PTEN产物PTEN蛋白的表达在肿瘤侵袭转移中的关系。方法　应用免疫组织化学S P法检测 98例浸润性乳腺癌组织MMP 2、MMP 9及TIMP 1和PTEN蛋白的表达。结果　乳腺癌MMP 2、MMP 9与PTEN表达呈显著负相关 ,而TIMP 1与PTEN蛋白表达呈显著正相关 (P <0 0 5 )。在PTEN低表达组中 ,MMP 2、MMP 9的表达与腋窝淋巴结受累呈正相关 ;在PTEN高表达组中 ,MMP 2、MMP 9的表达与腋窝淋巴结受累呈正相关 ,TIMP 1与腋窝淋巴结受累呈负相关。结论　在乳腺癌侵袭转移中MMP 2、MMP 9、TIMP 1与PTEN蛋白表达显著相关。MMP 2、MMP 9和TIMP 1对肿瘤细胞侵袭转移的作用可能在一定程度上受到PTEN的调控。? Objective To investigate the relationship between the protein expression of PTEN and gelatinases(MMP-2,MMP-9)and their inhibitor(TIMP-1) in invasion and metastasis of breast cancer. Method Immunohistochemical, S-P method was used to detect the positivity of PTEN, MMP-2,MMP-9 and TIMP-1 in 98 cases of invasive breast cancers. Result The protein expression of MMP-2 and MMP-9 was negatively correlated to that of PTEN, and the expression of TIMP-1 was positively correlated to that of PTEN(P<0.05). In the group of weak PTEN expression, the expression of MMP-2 and MMP-9 was positively correlated to axillary lymph node metastasis. In the group of strong PTEN expression, the expression of MMP-2 and MMP-9 was also positively correlated, while the expression of TIMP-1 was negatively correlated to axillary lymph node metastasis. Conclusion PTEN has a close relationship with the expression of MMP-2,MMP-9 and TIMP-1 in breast cancer invasion and metastasis. The effect of MMP-2, MMP-9 and TIMP-1 might be partly under the regulation of PTEN in cancer cell invasion and metastasis.

关 键 词：明胶酶 乳腺癌 抑癌基因 PTEN 免疫组织化学 

分 类 号：R737.9[医药卫生—肿瘤]