一定参数的磁场在不同生物层次上抑制恶性肿瘤生长  

Magnetic Fields with Fixed Parameters Inhibit Malignant Tumour Growth at Different Biological Levels

作　　者：张沪生[1] 

机构地区：[1]武汉大学物理学院生物医学物理研究室,430072

出　　处：《生物磁学》2004年第2期1-4,共4页Biomagnetism

基　　金：国家自然科学基金 ( 39870 82 3)资助课题

摘　　要：目的 :在不同生物层次上观测一定参数的磁场抑制恶性肿瘤生长。方法 :用脉冲梯度磁场 (峰值磁场 0 .6- 2 .0T ,磁场梯度 1 0 - 1 0 0T·M - 1 ,脉冲宽度 2 0 - 2 0 0ms,重复频率 0 .1 6- 1 .34Hz)治疗白鼠 ,在不同生物层次上 ,例如生物活体、器官、组织、细胞和大分子 ,能抑制鼠恶性肿瘤生长。结果 :上述磁场诱导癌细胞凋亡和阻塞供应肿瘤的新生血管。磁场对运动离子的洛仑兹力 ,使它们束缚在拉莫尔 (Larmor)半径以内 ,会影响正负带电离子对细胞膜和核膜的渗透能力 ,甚至在细胞膜和核膜上形成空洞。结论 :由于这一磁场抑制癌瘤生长 ,所以它能成为一种治疗癌瘤的新方法。Objective: Observations on inhibitory effects of magnetic fields with fixed parameters on malignant tumour growth at different biological levels. Methods: Pulsed-gradient magnetic fields with the maximum intensity of 0.6-20 T, gradient of 10-100 T·M-1, pulse width of 20-200 ms and frequency of 0.16-1.34 Hz, treatment of mice can inhibit murine malignant tumour growth, as seen from analyses at different hierarchical levers, from organism, organ, to tissue, and down to cell and macromolecules. Results: Such magnetic fields induce apoptosis of cancer cells, and arrest neoangiogenesis, preventing a supply developing to the tumour. By Lorentz force the magnetic field keeps the moving ions within bounds of Larmor radius. Thus, penetrating capability of the positive and negative ions through the cell and nuclear membrane was affected, even the role on the cell and nuclear membrane formed. Conclusion: The growth of sarcomas might be amenable to such new method of treatment.

关 键 词：磁场 恶性肿瘤 生物层次 凋亡 细胞膜 核膜 

分 类 号：R73-33[医药卫生—肿瘤] R312[医药卫生—临床医学]