牛磺酸抑制大鼠血管平滑肌细胞增殖  

TAURINE INHIBITS VASCULAR SMOOTH MUSCLE CELL PROLIFERATION OF RAT

作　　者：牛大地[1] 张居馨 迟学栋 周洪[1] 杨青[1] 陈晓彤[1] 王述姮[1] 唐朝枢[1] 

机构地区：[1]北京医科大学心肺内分泌研究室

出　　处：《北京医科大学学报》1993年第4期255-257,共3页Journal of Peking University(Health Sciences)

摘　　要：以~3H-胸腺嘧啶参入和细胞计数的方法,观察牛磺酸对血管平滑肌细胞(VSMC)增殖的抑制效应。结果表明,培养液中加入牛磷酸(5、10和20mmol/L)能明显抑制培养的自发性高血压大鼠(SHR)和正常血压大鼠(WKY)VSMC的~3H-胸腺嘧啶参入,降低其细胞计数。牛磺酸对血管紧张素Ⅱ(10^(-7)mmol/L)刺激的VSMC增殖亦呈剂量依赖地抑制效应。This paper reports for the first time on the growth-inhibiting effect of taurine on vascular smoothmuscle cells (VSMCs) of rat. Addition of taurine (5,10 and 20 mmol/L) into culture medium signi-ficantly reduced ~3H-thymidine incorporation of VSMCs in spontaneously hypertensiye rats (SHR) andnormotensive WKY rats, and lowered their cell counts. In addition, proliferation of VSMCs stimulatedby angiotensin Ⅱ was also markedly inhibited by taurine in a dose-dependent manner. The cell proli-feration-inhibiting effect of taurine might have a therapeutic and preventive significance for diseasesrelative to VSMC proliferation.

关 键 词：牛磺酸 血管 平滑肌细胞 高血压 

分 类 号：R965.1[医药卫生—药理学]