基质金属蛋白酶-10在人成釉细胞瘤中的表达  

Expression of Matrix metalloproteinases-10 in human ameloblastoma

作　　者：钟鸣[1] 仇丽鸿[1] 王洁[1] 

机构地区：[1]中国医科大学口腔医学院病理科,沈阳110002

出　　处：《现代口腔医学杂志》2004年第3期208-210,共3页Journal of Modern Stomatology

摘　　要：目的　研究基质金属蛋白酶 - 10 (Matrixmetalloproteinase,MMP - 10 )在成釉细胞瘤 (ameloblastoma ,AB)中的表达 ,结合临床病理探讨其生物学行为。方法　用免疫组化SP法检测 37例ABMMP - 10的表达 ,同时以牙源性角化囊肿 (odontogenic ,keratocyst,OKC) 9例为对照。 结果　MMP - 10在 1例 (11.1% )OKC棘层细胞中有强阳性表达 ,基底层细胞表达较弱或丢失。在AB的外周层及星网状层细胞中强阳性表达 2 3例 (6 2 .2 % )。MMP - 10中AB与OKC相比P <0 .0 0 1。随着AB的复发阳性表达强度增加 ,表达率升高 ,原发AB ,7例阳性(4 3.8% ) ,复发AB ,16例阳性 (76 .2 % ) ,原发与复发AB相比 P <0 .0 5。MMP - 10的表达与患者的年龄、性别、部位、病理分型无关 (P >0 .0 5 )。结论　MMP - 10的高表达与AB的临床生物学行为相关 ,可能为该肿瘤侵袭性生长的因素之一。Objective To investigate the expression of matrix metalloproteinase-10(MMP-10) in human ameloblastoma(AB),and to explore the relationship between the biological behavior of AB and its clinicopathology.Methods The specimens of 37 of AB,9 odontogenic keratocysT(OKC) were examined immunohistochemically by using the streptavidin-biotin method to determine the expression of MMP-10.Results In the 9 OKC cases,MMP-10 expression was strongly positive in stratum spinosum in one case ( 11.1%) and weak or lost in stratum basale.MMP-10 was strongly expressed in the central and peripheral cells of the tumor islands in 23 cases of AB( 62.2%).There was a significant difference between these two groups (P< 0.001).The positive rate and intensity increased as AB recurred and transformed malignantly,MMP-10 was positive in 7 cases of primary AB( 43.8%) and 16 cases of recurrent AB( 76.2%).There was a significant difference between these two groups(P< 0.05).But the increases of MMP-10 expression were not associated with age,sex,pathological type,or tumor location(P> 0.05).Conclusion The high expression of MMP-10 is related to the biological behavior of AB.Imbalance in the expression of MMP-10 proteins is one mechanism for the invasion of AB.

关 键 词：基质金属蛋白酶-10 成釉细胞瘤 表达 生物学行为 免疫组化 牙源性角化囊肿 

分 类 号：R739.8[医药卫生—肿瘤]