利培酮和氟哌啶醇随机双盲治疗痴呆的行为和精神症状  

Risperidone vs haloperidol in treatment of behavioral and psychological symptoms of dementia: a randomized, double-blind trial

作　　者：盛建华[1] 高之旭[1] 陈美娟[1] 张明廉[2] 刘建农[3] 

机构地区：[1]上海市精神卫生中心,上海200030 [2]无锡市精神卫生中心,江苏无锡214151 [3]苏州市广济医院,江苏苏州215008

出　　处：《中国新药与临床杂志》2004年第6期359-362,共4页Chinese Journal of New Drugs and Clinical Remedies

摘　　要：目的 :评价利培酮和氟哌啶醇治疗痴呆的行为和精神症状的疗效和安全性。方法 :采用随机双盲对照研究 ,利培酮组 2 8例 ,剂量 (1.3±s 0 .5 )mg·d- 1,0 .5～ 2mg·d- 1。氟哌啶醇组 2 5例 ,剂量(2 .8± 0 .9)mg·d- 1,1～ 4mg·d- 1,疗程均 8wk。治疗前后进行阿尔采末病病理行为评分表 (BE HAVE AD)、Cohen Mansfield激越问卷 (CMAI)等量表评定及实验室检查。结果 :2组病人治疗后BEHAVE AD和CMAI评分显著下降 (P <0 .0 1) ,2组病人之间治疗后的BEHAVE AD和CMAI减分值无显著差异 (P >0 .0 5 )。 2组病人的不良反应均以锥体外系反应为主 ,利培酮组 2 3% ,氟哌啶醇组4 0 %。结论 :低剂量的利培酮和氟哌啶醇治疗BPSD疗效确切 ,病人耐受性好。AIM: To assess the efficacy and safety of risperidone and haloperidol in the treatment of behavioral and psychological symptoms of dementia (BPSD). METHODS: It was a randomized, double-blind trial. The dosage strategy was flexible. The course of treatment was 8 wk. Twenty-eight patients of risperidone group had taken risperidone (1.3± s 0.5) mg·d -1, 0.5-2 mg·d -1. Twenty-five patients of haloperidol group had taken haloperidol, (2.8± 0.9) mg·d -1, 1-4 mg·d -1. They were all examined with some relative scales, such as BEHAVE-AD and CMAI, and some laboratory tests. RESULTS: After treatment, the scores of BEHAVE-AD and CMAI of patients in both groups were significantly reduced (P<0.01) and there was no significant difference between them (P>0.05). The prominent adverse drug reactions of both drugs was extrapyramidal symptoms (EPS). The incidence of EPS was 23 % in risperidone group, 40 % in haloperidol group. CONCLUSION: Low-dose risperidone and haloperidol shows good efficacy for treating BPSD and good tolerance for patients.

关 键 词：痴呆 行为症状 心理生理性障碍 利培酮 氟哌啶醇 双盲法 随机对照试验 

分 类 号：R749.16[医药卫生—神经病学与精神病学] R971.4[医药卫生—临床医学]