Ｆｒｉｅｎｄ病毒诱发小鼠红白血病生物学特性的进一步研究  

作　　者：褚建新[1] 华国勋 丁立[1] 应红光[1] 李卫萍[1] 李景德 

机构地区：[1]中国医学科学院血液学研究所

出　　处：《北京实验动物科学》1993年第4期11-14,共4页

摘　　要：本文报道了F-MuLV诱发小鼠红白血病生物学特性的进一步研究结果。发现中国昆明小鼠和615小鼠对F-MuLV有明显抵抗。脾脏的原红细胞是该病毒的靶细胞,但切脾后仍可发病,这时骨髓成为该病毒的靶器官。因而提出,在正常动物中F-MuLV对脾红系细胞比骨髓更具有亲和性。砊his paper reported the resultS of further studies on　the biological characteristics of F-MuLV-induced mouse ery-throleukemia.It was found that the　Chinese Kunming and 615 strain micehave genetic resistance to NB-tropic F-MuLY.The dynamic observation on pathogenic processes of leukemia showed that the target cells of F-MuLV were the erythroblAstic cells in the spleen .But the erythrolcukemia still occurred in the mice after splenectomy.On this condition,the erythroblasts of the bone marrow became the tar -get cells of the virus. Authors indicated that in the intact mice the splenic erythroblasts were more sensitive to F-MuLV than that of bone

关 键 词：小鼠 红白血病 敏感性 弗氏病毒 

分 类 号：R－332[医药卫生]