^(153)Sm-EDTMP对小细胞肺癌与非小细胞肺癌骨转移的止痛疗效观察  

Clinical Dbservation of ^(153)Sm-EDTMP as A Palliative Treatment for Small Cell Lung Cancer and non-small Cell Lung Cancer Patient with Painful Bone Metastasis

作　　者：舒斌[1] 徐蓉生[1] 段云[1] 朱尤奇[1] 向光华[1] 赵力威[1] 

机构地区：[1]四川省肿瘤医院核医学科,四川成都610041

出　　处：《华西医学》2004年第2期201-202,共2页West China Medical Journal

基　　金：四川省肿瘤医院科研项目基金资助(No . 991 0 4 )

摘　　要：目的 :观察153 Sm -EDTMP (ethylenediaminetetramethylenephosphonicacid)对小细胞肺癌与非小细胞肺癌骨转移疼痛的临床疗效及副作用。方法 :对 1996年 6月至 2 0 0 2年 6月 16 8例经病理或细胞学确诊的肺癌骨转移疼痛病人做 1～ 3次153 Sm -EDTMP内照射治疗。肘静脉给药剂量为 2 9 6～ 37 0MBg/kg体重 ,骨转移灶经骨显像、X线片、CT或MRI确诊。结果 :治疗有效率 6 5 4 % ,其中完全缓解 2 1 4 % ,部分缓解 4 4 0 % ,无效 34 5 %。小细胞肺癌治疗有效率为 5 4 8% ,非小细胞肺癌治疗有效率为 6 7 9% ,二者无显著性差异。毒副作用轻微仅有15 6 % (2 6 / 16 8)的病人出现不同程序的WBC、Plt、Hb下降。结论 :153 Sm -EDTMP静脉注射是肺癌骨转移疼痛的有效治疗手段、副作用小、使用安全、可重复用药。Objective:To evaluate the toxicity of 153 Sm-EDTMP as a palliative treatment for small cell lung cancer and non-small cell lung cancer patients with painful bone metastasis.Methods:Between June,1996 to June,2002 168,lung cancers with painful bone metastasis were treated with 153 Sm-EDTMP at a varying dose of 29.6～37.0MBg/kg.All of the diagnosis was histologically confirmed.Bone metastasis was further diagnosed with ECT,X-ray,CT and/or MRI.Results:65.4% of patients had a positive response,with complete response 21.4% and partial response 44.0%,34.5% of patients showed no response.According to the pathology the positive response observed in 54.8% of patients with small cell lung cancer,67.9% of patients with non-small cell lung cancer.No serious side-effect was observed,except for falls in the white blood cells,platelet counts and hemoglobin in 15.6%(26/168)of the patients.Conclusion: 153 Sm-EDTMP was an effective treatment for lung cancer with painful bone metastasis,and the side-effect was mild,and it could be used repeatedly and safefully.

关 键 词：^153SM-EDTMP 小细胞肺癌 骨转移癌 止痛 疼痛 

分 类 号：R734.2[医药卫生—肿瘤] R738.1[医药卫生—临床医学]