Effect of intraoperative radiotherapy combined with external beam radiotherapy following internal drainage for advanced pancreatic carcinoma  

作　　者：Hong-BingMa Zheng-LiDi Xi-JingWang Hua-FenKang Huai-CiDeng Ming-HuaBai 

机构地区：[1]DepartmentofOncology,theSecondHospitalofXi'anJiaotongUniversity,Xi'an710004-ShaanxiProvince,China [2]DepartmentofRadiationOncology,theFirstHospitalofXi'anJiaotongUniversity,Xi'an710068,ShaanxiProvince,China [3]DepartmentofOncology,theSecondHospitalofXi'anJiaotongUniversity,Xi'an710004-ShaanxiProvince,China

出　　处：《World Journal of Gastroenterology》2004年第11期1669-1671,共3页世界胃肠病学杂志（英文版）

基　　金：Supported by the Technology Project Entry Foundation of ShaanxiProvince,No.2002K10-G3

摘　　要：AIM: To determine the survival of advanced pancreatic cancer patients treated with intraoperative radiotherapy (IORT) combined with external beam radiation therapy (EBRT) following internal drainage (cholecystojejunostomy or choledochojejunostomy). METHODS: Eighty-one patients with advanced pancreatic cancer who received IORT combined with EBRT following internal drainage (ID) between 1996 and 2001 were retrospectively analyzed. Among the 81 patients, 18 underwent ID+IORT, 25 ID+IORT+EBRT (meanwhile, given 5-Fu 300 mg/m^2 iv drip, 2f/w), 16 EBRT, 22 had undergone simple internal drainage. The IORT dose was 15-25Gy in a single fraction. The usual EBRT dose was 30-40Gy with a daily fraction of 1.8-2.0 Gy. RESULTS: The complete remission rate, partial remission rate of patients with backache and abdominal pain treated with ID+IORT were 55.5%, 33.3% respectively. Alleviation of pain was observed 2 or 3 wk after IORT. The median survival time (MST) of ID+IORT group was 10.7 mo. The pain remission rate of patients treated with ID+IORT+EBRT was 92%, and their MST was 12.2 mo. The MST of patients treated with EBRT and simple internal drainage was 5.1 mo and 7.0 mo, respectively. The survival curve of ID+IORT group and ID+IORT+EBRT group was significantly better than that of EBRT group (P<0.05). The difference between the ID+IORT+EBRT group and ID group was significant (P<0.05). CONCLUSION: IORT combined with EBRT following internal drainage can alleviate pain, improve quality of life and prolong survival time of patients with advanced pancreatic cancer.AIM:To determine the survival of advanced pancreatic cancer patients treated with intraoperative radiotherapy (IORT) combined with external beam radiation therapy (EBRT) following internal drainage (cholecystojejunostomy or choledochojejunostomy). METHODS:Eighty-one patients with advanced pancreatic cancer who received IORT combined with EBRT following internal drainage (ID) between 1996 and 2001 were retrospectively analyzed.Among the 81 patients,18 underwent ID+IORT,25 ID+IORT+EBRT (meanwhile,given 5-Fu 300mg/m^2 iv drip,2f/w),16 EBRT,22 had undergone simple internal drainage.The IORT dose was 15-25Gy in a single fraction.The usual EBRT dose was 30-40Gy with a daily fraction of 1.8-2.0 Gy. RESULTS:The complete remission rate,partial remission rate of patients with backache and abdominal pain treated with ID+IORT were 55.5%,33.3% respectively.Alleviation of pain was observed 2 or 3 wk after IORT.The median survival time (MST) of ID+IORT group was 10.7 too.The pain remission rate of patients treated with ID+IORT+EBRT was 92%,and their MST was 12.2 mo.The MET of patients treated with EBRT and simple internal drainage was 5.1 mo and 7.0 mo,respectively.The survival curve of ID+IORT group and ID+IORT+EBRT group was significantly better than that of EBRT group (P<0.05).The difference between the ID+IORT+EBRT group and ID group was significant (P<0.05). CONCLUSION:IORT combined with EBRT following internal drainage can alleviate pain,improve quality of life and prolong survival time of patients with advanced pancreatic cancer.

关 键 词：外科手术 放射线疗法 胰腺癌 晚期 IORT EBRT 物理治疗 

分 类 号：R735.9[医药卫生—肿瘤] R454[医药卫生—临床医学]