α-内收蛋白基因G614T多态性与出血性脑卒中发病无关  

No relationship between G 614 T polymorphism in α-adducin gene and hemorrhagic stroke

作　　者：赵勇[1] 孙慧[2] 马丽媛[3] 王建春[1] 孙金凤[2] 邵建华[1] 刘力生[3] 

机构地区：[1]山东省立医院保健科,山东济南250021 [2]山东省济南市中心医院,山东济南250013 [3]中国医学科学院中国协和医科大学心血管病研究所阜外心血管病医院,北京100037

出　　处：《中国急救医学》2004年第6期407-408,共2页Chinese Journal of Critical Care Medicine

摘　　要：目的　了解α-内收蛋白基因G6 14T多态性与中国人群出血性脑卒中之间的关系。目的　利用PCR和分子杂交技术对该位点在中国人群出血性脑卒中患者 ( 2 0 2例 )中的分布进行了检测和分析 ,并与无脑血管病变的人群 ( 190例 )进行比较。结果　中国人群G6 14T多态性分布符合Hardy -Weinberg遗传平衡定律 ,GG、GT、TT三种基因型在病例组中分布频率分别为 2 8 71%、4 6 5 3%和 2 4 75 % ,对照组中分别为 2 5 79%、5 1 0 5 %和 2 3 16 % ;两组人群中 6 14T等位基因频率分别为4 8 0 2 %和 4 8 6 8% ,均无统计学明显差异。结论　α -内收蛋白基因G6Objective To evaluate the relationship between the G614T polymorphism in α-adducin gene and the hemorrhagic stroke in Chinese population.Methods 202 patients with hemorrhagic stroke and 190 controls without stroke were examined by polymerase chain reaction(PCR)and corresponding probe hybridization.Results The G614T polymorphism was in agreement with Hardy-Weinberg equilibrium.The prevalence rates of GG,GT and TT genotypes were 28 71%,46 53%and 24 75% in the patients;and 25 79%,51 05% and 23 16% in controls,respectively.The 614T allele frequencies were 48 02% in the patients and 48 68% in controls.No significant differences in both genotypes and allele of G614T polymorphism were observed between cases and controls.Conclusion The G614T polymorphism of α-adducin gene may not be a genetic marker of hemorrhagic stroke in Chinese population.

关 键 词：Α-内收蛋白 基因多态性 出血性脑卒中 G614T 脑血管病 分子遗传学 

分 类 号：R743.3[医药卫生—神经病学与精神病学]