少见型角化棘皮瘤的诊断与治疗  

Diagnosis and treatment in cases of unusual type of keratoacanthoma

作　　者：王玉坤[1] 郭淑兰[1] 王克玉[1] 刘金耀[1] 

机构地区：[1]山东大学齐鲁医院皮肤科,济南250012

出　　处：《中国麻风皮肤病杂志》2004年第3期222-225,共4页China Journal of Leprosy and Skin Diseases

摘　　要：目的 :　探讨少见型角化棘皮瘤 (KA)的诊断及治疗方法。方法 :　对 2例病人的临床和组织学表现进行分析 ,观察了阿维A的治疗效果 ,并对相关文献作了复习。结果 :　 2例组织学改变均符合KA。根据它们的临床表现和组织学特征 ,分别诊断为边缘离心性KA和发疹性KA。口服阿维A 2 0～ 30mg d ,2个月 ,皮损全部消退。结论 :　少见型KA依据临床和组织病理学特征可作出诊断。阿维A可作为治疗该型KA的首选药物。Objective:To explore the diagnosis and treat ment of patients with unusual type of keratoacanthoma (KA). Methods: The clinical and histological findings as well as the efficacy of ac itretin therapy were analyzed. In addition,the pertinent literatures were revie wed. Results: The histological changes in both cases were in accordance with KA. According to the clinical manifestations and histological changes,one case was diagnosed as keratoacanthoma centrifugum marginatum and t he another one as eruptive keratoacanthoma. The differential diagnosis of these two types of KA was discussed. Oral acitretin therapy was performed at 20～30 mg /d,and the skin lesions completely disappeared within two months. Conclusion :The diagnosis of these two types of KA can be confi rmed by clinical and histological features. Oral acitretin in a low dosage could be the first choice for the treatment of these types of KA.

关 键 词：少见型角化棘皮瘤 KA 组织学 皮肤肿瘤 临床资料 

分 类 号：R739.5[医药卫生—肿瘤]