^(18)FDG注射液放化纯度的测定  

Determination of Radiochemical Purity of ^(18)F-fluorodeoxyglucose Injection

作　　者：叶肇云[1] 齐秀珍[1] 

机构地区：[1]中国原子能科学研究院同位素研究所,北京102413

出　　处：《同位素》2004年第2期104-107,共4页Journal of Isotopes

摘　　要：采用薄层色谱和纸色谱法对不同的展开体系进行筛选,找到了三种适宜的展开体系,建立了测定18FDG注射液放化纯度的分析方法。这三种体系固定相分别为ITLC/SG、WhatmanNo.1层析纸和国产硅胶纸,相应的流动相分别为V(乙腈)∶V(水)=95∶5、V(甲醇)∶V(氨水)=9∶1、甲醇,三种展开体系的主产物18FDG与18F-均可较好地分离,精密度均<1%。A practical method is established for determining the radiochemical purity of ^(18)FDG rapidly. It offers three systems to separate ^(18)FDG and ^(18)F^-. The stationary phase of these are ITLC/SG? Whatman No.1 and silica paper, their corresponding mobile phase are V(acetionitril)∶V(water)=95∶5, V(methanol)∶V(water)=9∶1 and methanol, respectively. Twelve batchs of()^(18)FDG are determined, its radiochemical purity is more than 96%. The precision is less than 1%.

关 键 词：放化纯度 ^18FDG 薄层色谱 纸色谱 

分 类 号：O657.7[理学—分析化学] R817[理学—化学]