卡培他滨抑制肝细胞癌肺转移的临床观察  

A clinical study on inhibition of lung metastasis of hepatocellular carcinoma by capecitabine

作　　者：周俭[1] 樊嘉[1] 吴志全[1] 汤钊猷[1] 邱双健[1] 肖永胜[1] 孙绮蛮[1] 史颖弘[1] 叶胜龙[1] 

机构地区：[1]复旦大学肝癌研究所和中山医院肝外科,上海市200032

出　　处：《中华肝胆外科杂志》2004年第5期337-339,共3页Chinese Journal of Hepatobiliary Surgery

基　　金：国家重点基础研究发展规划 (G19980 5 12 11);上海市"医苑新星"基金;上海市高等学校青年科学基金 ( 0 2JG0 5 0 3 5 )资助项目

摘　　要：目的　探讨卡培他滨对肝细胞癌 (HCC)肺转移的抑制作用。方法　用免疫组织化学法检测 10例HCC及其肺转移灶组织中血小板衍化内皮细胞生长因子 (PD ECGF)的表达 ;3例肝癌切除术后复查发现肝癌肺转移的病人采用PD ECGF相关的卡培他滨化疗 (剂量为 12 5 0mg/m2 ,2次 /d ,口服持续 14d ,再停止 7d ,2 1d为一个化疗周期 ) ;每例病人 5～ 6个周期。结果　 10例HCC组织中有 7例表达PD ECGF ,癌周正常肝组织中表达率仅 30 % (3/ 10 ) ,而其肺转移灶组织中有 8例表达。3例病人均能耐受卡培他滨治疗 ,未见严重的化疗并发症。 1例口服卡培他滨疗程结束后复查发现肿瘤完全缓解 ,肺转移灶消失 ;1例肺转移灶稳定无进展 ;1例肺转移灶进展并转移至脑部。 3例病人发现肝癌肺转移后生存分别已达 18、13和 5个月。结论　PD ECGF在HCC肺转移灶组织中高表达 。Objective To study the inhibitory effects of capecitabine, a new tumor-selective chemotherapeutic agent, on lung metastasis of hepatocellular carcinoma (HCC). Methods Expression of platelet-derived endothelial cell growth factor (PD-ECGF) in 10 HCC tissues and 10 lung metastatic tissues of HCC were determined with immunohistochemistry. Three cases of lung metastasis of HCC were treated with intermittent oral administration of capecitabine at a dose of (1 255) mg/M^2 twice daily (two-week treatment followed by a one-week rest period as one cycle) after liver cancer removal. Each patient received 5-6 cycles of treatment with capecitabine. Results The rate of expression of PD-ECGF in HCC and its lung metastatic tissues was 70% and 80%, respectively, whereas that in the nontumoral liver tissue was only 30%. All the 3 patients could tolerate the treatment with capecitabine. Complete response of lung metastasis was observed in 1 patient, lung metastasis was stable in 1 and brain metastasis was found in the third one. The survival time in the 3 patients after lung metastasis was 18, 13 and 5 months, respectively. Conclusions PD-ECGF is highly expressed in lung metastatic tissue of HCC. Oral administration of capecitabine may be one of the effective measures to inhibit the lung metastasis of HCC.

关 键 词：卡培他滨 抑制 肝细胞癌 肺转移 临床观察 

分 类 号：R735.7[医药卫生—肿瘤]