国产铝碳酸镁治疗胆汁反流性胃炎和24小时胆汁监测  

Efficacy of home made hydrotalcite in treating bile reflux gastritis and 24-hour intragastric bile monitoring

作　　者：叶萍[1] 李兆申[1] 许国铭[1] 邹多武[1] 尹宁[1] 

机构地区：[1]上海第二军医大学附属长海医院消化内科,200433

出　　处：《中华消化杂志》2004年第5期263-265,共3页Chinese Journal of Digestion

摘　　要：目的　评估国产铝碳酸镁 (威地美 )和进口同类产品 (达喜 )治疗胆汁反流性胃炎的疗效及安全性。方法　 30例伴有腹痛、反酸、恶心、呕吐胆汁患者由胃镜诊断为胆汁反流性胃炎 ,并经胃内 2 4h胆汁监测证实。患者分为两组 ,试验组 15例 ,给予国产铝碳酸镁 1.0 g ,每天 3次 ;对照组 15例 ,给予进口产品 1.0 g ,每天 3次 ,疗程均为 4周。治疗前、后均采用Bilitec测定胃内胆汁酸。观察治疗前后临床症状积分、临床症状消失时间、胃内胆汁酸变化以及药物不良反应。结果　试验组治疗 2、4周后烧心、上腹痛、上腹胀、嗳气、反酸、呕吐胆汁样物等症状均明显减轻 (P <0 .0 5 ) ,总有效率为 10 0 %。与对照组相比疗效相当。两组在治疗过程中 ,烧心、上腹痛、上腹胀、嗳气、反酸、呕吐胆汁样物等症状的消失时间也相当。试验组腹痛完全消失时间为 (7.2± 3.1)d ,对照组为 (6 .9± 4 .8)d。Bilitec监测结果显示 :试验组 2 4h胃内胆汁反流总时间百分比由治疗前的 (17.0± 16 .3) %降至 (4.9± 4 .5 ) % (P <0 .0 5 ) ,对照组由治疗前的 (16 .8± 6 .9) %降至 (3.2± 2 .3) % (P <0 .0 5 )。两组均未见明显的不良反应。结论　国产铝碳酸镁可结合胃内胆汁 ,有效缓解胆汁反流性胃炎症状 ,是治疗胆汁反流性胃炎安全。Objective To evaluate the efficacy and safety of two kinds of hydrotalcite, Weidimei and Talcid, in treating bile reflux gastritis. Methods Thirty patients with bile reflux gastritis confirmed by endoscopy were equally divided into experimental group (Weidimei) and control group (Talcid). The patients were given Weidimei or Talcid both at the dose of 1.0 g 3 times a day for 4 weeks, respectively. The severity of the symptoms including abdominal pain, regurgitation, nausea and vomiting of bile were investigated before and after the treatment. Twenty four hour bile in stomach was monitored. Results The severity of all symptoms greatly decreased after the treatment in two groups ( P <0.05). The total efficiency was 100%. The mean disappearance time of abdominal pain was (7.2±3.1) days in experimental group, and (6.9 ±4.8) days in control group . The total fraction time of bile reflux decreased from (17.0±16.3)% to (4.9 ±4.5)% ( P <0.05) in experimental group, and from (16.8± 6.9)% to (3.2± 2.3)% in control group ( P <0.05).No side effect was found in two groups. Conclusion Two kinds of hydrotalcite can combine intragastric bile and is effective and safe in the treatment of bile reflux gastritis.

关 键 词：铝碳酸镁 胆汁反流性胃炎 24小时 胆汁监测 药物治疗 

分 类 号：R573.3[医药卫生—消化系统]