子宫肌瘤患者的血清雌激素与瘦素水平分析  

Association between serum estrogen level and leptin in the patients with carcinoid in uterine

作　　者：张亚兰[1] 卢丹[1] 冯迟[1] 史樱[1] 

机构地区：[1]首都医科大学附属北京妇产医院妇科,100026

出　　处：《北京医学》2004年第3期159-160,共2页Beijing Medical Journal

摘　　要：目的　探讨瘦素与雌激素在子宫肌瘤发病中的意义。方法　对 5 3例子宫肌瘤患者子宫全切术前(卵泡期 )测定血清瘦素 (leptin)、促卵泡素 (FSH)、促黄体生成素 (LH)、雌二醇 (E2 )、睾酮 (T)水平 ,并与正常对照组雌激素水平进行比较。对病例组中的雌激素、睾酮与瘦素水平进行相关性分析。结果　子宫肌瘤患者的血清雌二醇水平与对照组无显著性差异 (Dt=- 0 .0 1 2 ,P =0 .91 2 )。子宫肌瘤患者的血清雌二醇水平与瘦素水平呈正相关(r =0 .2 1 6 ,P =0 .346 ) ;睾酮与瘦素水平也呈正相关 (r=0 .0 76 ,P =0 .74 3)。结论　瘦素与子宫肌瘤的发生、发展有关。Objective To study the significance of estrogen and leptin in the pathogenesis of carcinoid in uterine.Methods The concentration of leptin and FSH?LH?E 2?T in 53 patients with carcinoid in uterine was measured.We compared the concentration and estrogen in the patients with carcinoid in uterine and the controls.The estrogen,testeostone and leptin in the patients were compared for persistence.Results The difference of serum concentration of estrogen in the patients with carcinoid in uterine and the controls was not significant ( t =-0.012, P =0.912).The estrogen was directly correlated with leptin ( r=0.216,P =0.346),while testerone was positively correlated with leptin ( r=0.076,P =0.743).Conclusions Leptin may be involed in the pathogenesis of carcinoid in uterine.

关 键 词：子宫肌瘤 血清 雌激素 瘦素 睾酮 

分 类 号：R737.33[医药卫生—肿瘤]