从循证医学角度谈早期肺癌的筛查  

Evidence-Based Lung Cancer Screening in the Early Stage

作　　者：董碧蓉[1] 何萍[1] 

机构地区：[1]四川大学华西医院老年科,成都610041

出　　处：《中国循证医学杂志》2004年第6期419-422,共4页Chinese Journal of Evidence-based Medicine

摘　　要：本文对普通胸片、痰细胞学检查和低剂量CT在肺癌筛查中的作用以及各种临床试验的研究设计、偏倚等进行了分析 ,从循证医学角度阐述了单纯胸片筛查或联合痰脱落细胞学检查均不能降低肺癌死亡率 ;尽管低剂量CT能够检测到大多数无症状性肺癌和早期可切除的肺癌 ,但有过度诊断和研究设计仅限于观察性试验的不足 。Lung cancer is the leading cause of death among the tumors in the whole world. Although new diagnostic techniques have been developed for nearly 20 years, the mortality is still high. Until now, no randomized controlled trial of chest x-ray and sputum cytology showed the improvement of the survival rate of lung cancer. Low-dose CT can screen more patients in early stage, however, overdiagnosis, cost and the quality of studies should be considered. Further studies of RCTs should be done to clarify these questions.

关 键 词：肺癌筛查 胸片 低剂量CT 痰细胞学 

分 类 号：R734.204[医药卫生—肿瘤]