单侧磨牙缺失对大鼠海马神经递质含量的影响  

Effects of unilateral molarless on neurotransmitters in hippocampus of rats

作　　者：江青松[1] 姜婷[1] 冯海兰[1] 吴敏节[1] 石川达也[2] 下野正基[2] 张建军[3] 

机构地区：[1]北京大学口腔医学院修复科 [2]东京齿科大学 [3]中国医学科学院药物研究所,副研究员北京100050

出　　处：《口腔颌面修复学杂志》2004年第2期76-78,共3页Chinese Journal of Prosthodontics

基　　金：中华医学专项人才基金资助项目(CMB2000)

摘　　要：目的:研究单侧磨牙缺失对大鼠脑部海马区主要神经递质含量的影响。方法:23只10月龄Wistar大鼠随机分为对照组和左侧磨牙拔除组,六周后,大鼠快速断头处死,分离海马区脑组织,拔牙组海马左右侧分开,分别测定氨基酸类和单胺类神经递质的含量。结果:①拔牙组左、右侧海马中g-氨基丁酸(GABA)和牛磺酸(Tau)含量与对照组比较均升高(P<0.05);②拔牙组左、右侧海马中5-羟吲哚乙酸(5-HIAA)含量、5-HIAA/5-HT比值与对照组比较均降低(P<0.001);③拔牙组大鼠左侧海马内谷氨酸(Glu)含量与对照组比较升高(P<0.05);④拔牙组大鼠右侧海马内去甲肾上腺素(NE)和5-羟色胺(5-HT)含量与对照组比较升高(P<0.05)。结论:单侧磨牙缺失后影响大鼠海马区氨基酸类和单胺类神经递质水平。Objective: To study the effects of unilateral molarless on neurotransmitters concentration in hippocampusof rats. Methods: 23 Wistar rats (10 months old) were randomly divided into the two groups: a unilateral molars extractiongroup (left molars) and a control group. Six weeks later, all animals were decapitated and the hippocampus was dissected(separating into left and right hippocampus in molarless group) to measure the amino acid neurotransmitters and monoamineneurotransmitters concentration. Results: Compared with the control group: In the bilateral hippocampus of molarlessgroup, contents of gama-aminobutyric (GABA) and taurine (Tau) were significantly increased (P<0.05), but the contents of 5-hydroxyindole acetic acid (5-HIAA) and 5-HIAA/5-HT were decreased significantly (P<0.001); In the left hippocampus, thecontent of glutamate (Glu) were significantly increased (P<0.05), and in the right, the contents of nor-adrenalin (NE) and 5-hydroxytryptmine (5-HT) were significantly increased (P<0.05). Conclusion: Within the limitation of this study, unilateralmolarless may alter the content of the amino acid and monoamine neurotransmitters in hippocampus of rats.

关 键 词：单侧磨牙缺失 大鼠 海马 神经递质 含量 

分 类 号：R780.2[医药卫生—口腔医学]