应用核磁共振技术研究盐酸非索非那定与β-环糊精包合的相互作用  

The Interaction Study of the Inclusion of Fexofenadine with β-Cyclodextrin by NMR

作　　者：潘洁[1] 赵玉静 赵玉梅[3] 

机构地区：[1]军事医学科学院放射与医学研究所,北京 [2]军事医学科学院附属医院,北京 [3]军事医学科学院毒物药物研究所,北京

出　　处：《分析化学进展》2017年第1期16-20,共5页Advances in Analytical Chemistry

摘　　要：目的:研究溶液状态下盐酸非索非那定(FFD)与β-环糊精相互作用过程以及包合物立体构型。方法:应用核磁共振(NMR)技术如1D-NMR和2D-ROESY的方法研究了盐酸非索非那定(FFD)与β-环糊精在水溶液中的包合过程以及包合物的立体结构。结论:根据FFD/β-CD不同比例包合物1H-NMR中化学位移的变化以及2D-ROESY,可以判定,盐酸非索菲那定与β-环糊精发生了包合,而且当比例为1:1时,主要是单取代苯环进入β-CD空腔内,而且是从β-CD的宽口进入。Objects: To study the interaction between Fexofenadine and β-cyclodextrin and the geometry structure of the complexation in solution. Methods: The interaction study of the inclusion between fexofenadine and β-cyclodextrin in aqueous solution was attempted by 1H-NMR and 2D-ROESY. Conclusion: The results of 1H-NMR of chemical shift changes and 2D-ROESY in different proportion complexation suggest that there was interaction between FFD and β-CD, and when the molar ratio of fexofenadine to β-cyclodextrin is one, the p-phenyl ring of fexofenadine is predominantly included within β-cyclodextrin cavity, which penetrates deep from the wider rim.

关 键 词：盐酸非索非那定 Β-环糊精 包合物 核磁共振 2D-ROESY 立体结构 

分 类 号：R28[医药卫生—中药学]