核磁共振波谱仪在制药工程专业本科实验教学中的改革和探索——以“阿司匹林的制备”实验为例  

Application and Exploration of Nuclear Magnetic Resonance Spectroscopy in Undergraduate Experimental Teaching of Pharmaceutical Engineering Majors—Taking “Preparation of Aspirin” Experiment as an Example

作　　者：晋海洋 惠永海 张永飞 高利军 王赟 

机构地区：[1]岭南师范学院化学化工学院,广东 湛江

出　　处：《分析化学进展》2024年第4期222-228,共7页Advances in Analytical Chemistry

摘　　要：核磁共振波谱在药物发现、药物结构鉴定和药物质量控制等方面具有重要作用。针对核磁共振波谱实验在制药工程专业本科实验教学中存在的问题,对制药工程专业核磁共振波谱实验进行了改革和探索,并以“阿司匹林的制备”实验为例对核磁测试方法和药物分子的核磁谱图解析进行了详细说明。这种改革方式为应用大型贵重仪器提高制药工程专业人才培养质量提供了新的视角。Nuclear magnetic resonance spectroscopy has an important role in drug discovery, drug structure identification and drug quality control. Aiming at the problems existing in the undergraduate experimental teaching of pharmaceutical engineering, the NMR spectroscopy experiment of pharmaceutical engineering has been reformed and explored, and the NMR test method and the NMR spectra analysis of drug molecules have been described in detail by taking the experiment of “Preparation of Aspirin” as an example. This mode of reform provides a new perspective for the application of large and valuable instruments to improve the quality of training for pharmaceutical engineering professionals.

关 键 词：核磁共振波谱实验 药物合成实验 实验教学 阿司匹林 

分 类 号：R28[医药卫生—中药学]