髓源性抑制细胞在结直肠癌复发转移中的研究进展  

Research Progress of Myeloid Derived Suppressor Cells in Recurrence and Metastasis of Colorectal Cancer

作　　者：王治宽[1] 司海燕[1] 周艳华[1] 戴广海[1] 

机构地区：[1]解放军总医院肿瘤内科,北京

出　　处：《临床医学进展》2018年第10期902-909,共8页Advances in Clinical Medicine

摘　　要：髓源性抑制细胞是骨髓来源的一群异质性细胞,具有显著抑制免疫细胞应答的能力。MDSCs在结直肠癌的复发转移过程中,对Tregs具有正向调控作用,抑制机体正常的抗肿瘤免疫,免疫抑制导致CTC免疫逃逸,通过TME促进肿瘤转移。MDSCs仍有许多作用机制未被阐明,还需要我们投入更大的精力,为预防肿瘤的复发转移及免疫治疗做出贡献。Myeloid derived suppressor cells (MDSCs) are a group of heterogeneous cells derived from bone marrow, which have remarkable ability of suppressing immune cell response. MDSCs have a posi-tive regulatory effect on Tregs in the process of recurrence and metastasis of colorectal cancer. It inhibits the normal anti-tumor immunity of the body. Immunosuppression leads to immune escape of CTC and promotes tumor metastasis through TME. There are still many mechanisms of MDSCs that have not been elucidated, and we need to devote more efforts to prevent recurrence and metastasis of tumors and immunotherapy.

关 键 词：髓源性抑制细胞 结直肠癌 复发转移 

分 类 号：R73[医药卫生—肿瘤]