磁共振弥散张量成像对于阿尔茨海默病早期诊断价值  

The Value of Magnetic Resonance Diffusion Tensor Imaging (DTI) Technology in the Early Diagnosis of Alzheimer’s Disease

作　　者：汪克为 张慧 邹良玉[1,2] 

机构地区：[1]暨南大学第二临床医学院(深圳市人民医院),广东深圳 [2]南方科技大学第一附属医院,广东深圳

出　　处：《临床医学进展》2018年第10期922-929,共8页Advances in Clinical Medicine

基　　金：深圳市卫计委资助项目(201601015);深圳市科技计划项目(JCYJ20160422170522075).

摘　　要：阿尔茨海默病(Alzheimer’s disease, AD)是一种起病隐匿的进行性进展的中枢神经系统退行性疾病,占所有痴呆类型的50%~70%。近年来,随着磁共振成像技术的成熟,利用磁共振弥散张量成像(Diffusion tensor imaging, DTI)技术发现在早期AD患者脑白质中存在异常改变,这可能为AD早期诊断寻找到新的影像学标志。本文结合国内外最新研究成果,就DTI在AD的早期诊断中的应用进行综述。Alzheimer's disease (AD) is a progressive, central nervous system degenerative disease that ac-counts for 50% - 70% of all dementia types. In recent years, with the maturity of magnetic reso-nance imaging technology, magnetic resonance diffusion tensor imaging (DTI) technology has been found to have abnormal changes in the white matter of early AD patients, which may help us find new imaging markers for early diagnosis of AD. This article summarizes the application of DTI in the early diagnosis of AD by combining the latest research results both in China and abroad.

关 键 词：阿尔茨海默病 扩散张量成像 早期诊断 

分 类 号：R74[医药卫生—神经病学与精神病学]