人树突状细胞亚群在抗肿瘤免疫中的作用  

The Role of Human Dendritic Cell Subsets in Antitumor Immunity

作　　者：马莉莉 程春来 谷飞飞[2] 

机构地区：[1]长江航运总医院肿瘤科,湖北 武汉 [2]华中科技大学同济医学院附属协和医院肿瘤中心,湖北 武汉

出　　处：《临床医学进展》2020年第3期232-238,共7页Advances in Clinical Medicine

摘　　要：树突状细胞是人体功能最强大的抗原递呈细胞,在诱导和调控机体针对病原体、自身抗原和癌症的免疫应答中发挥关键作用。树突状细胞是一群异质性细胞,不同的亚群具有独特的表型和功能。基于单核细胞来源的树突状细胞的治疗性疫苗在恶性肿瘤的治疗中显示出一定的疗效,其他树突状细胞亚群在抗肿瘤免疫中也发挥着重要作用。目前,还没有文献对不同树突状细胞亚群在抗肿瘤免疫中的作用进行系统性地阐述。为此,我们对人树突状细胞亚群的生物学特征及其在抗肿瘤免疫中的作用进行综述。Dendritic cells (DCs) are the most potent antigen presenting cells (APC) and critical regulators of immune responses. They play a key role in initiating and regulating the immune responses to pathogens, self-antigens, and cancers. DCs are heterogeneous and highly specialized antigen-presenting cells. Monocyte-derived DCs (MoDC) based therapeutic vaccines have been applied in the treatment of malignancies and showed certain efficacy. And the other dendritic cell subsets also play an important role in antitumor immunity. However, there is no literature that summarizes the roles of different dendritic cell subsets in antitumor immunity until now. Therefore, we reviewed the biological characteristics of human dendritic cell subsets and their roles in antitumor immunity.

关 键 词：树突状细胞 抗肿瘤免疫 免疫应答 抗原递呈细胞 肿瘤 

分 类 号：R73[医药卫生—肿瘤]