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作 者:周桂藏
机构地区:[1]青岛大学医学部儿科系,山东 青岛
出 处:《临床医学进展》2020年第7期1162-1167,共6页Advances in Clinical Medicine
摘 要:目的:通过对芳香化酶抑制剂联合基因重组人生长激素治疗大骨龄矮身材儿童疗效的分析,为大骨龄矮身材儿童的治疗提供临床依据。方法:选取2017年10月至2019年10月在青岛市妇女儿童医院内分泌代谢科诊断为矮身材、骨龄 ≥ 13岁的男童,同时应用来曲唑和基因重组人生长激素治疗,观察基线、治疗6个月、12个月疗程结束后的身高、体重、生长速率、骨龄、预测成年身高、睾酮、胰岛素样生长因子-1的变化及副作用。结果:芳香化酶抑制剂联合基因重组人生长激素治疗后患儿睾酮、胰岛素样生长因子-1水平明显升高,骨龄进展缓慢,生长速率、预测成年身高改善,差异有统计学意义(P 0.05),且安全性及耐受性良好。结论:芳香化酶抑制剂联合基因重组人生长激素治疗大骨龄矮身材男童可延缓骨龄进展,改善预测成年身高,近期安全性及耐受性良好。Objective: To analyze the efficacy of aromatase inhibitor combined with recombinant human growth hormone and provide a clinical basis for the treatment of boys with larger bone age. Methods: All the boys diagnosed as short stature and bone age ≥ 13 years in the Department of Endocrinology and Metabolism, Qingdao Women and Children Hospital from October 2017 to October 2019, both are treated with aromatase inhibitor and recombinant human growth hormone. Observe the changes in height, weight, growth velocity, bone age, predicted adult height, testosterone, insulin-like growth factor-1 and side effects after baseline, 6 months and 12 months of treatment. Results: After treatment with aromatase inhibitor and recombinant human growth hormone, the testosterone and insulin-like growth factor-1 levels in the children increased significantly, the bone age progressed slowly, and growth velocity and predicted adult height are improved, which was statistically significant (P 0.05), and the safety and tolerability were good. Conclusions: Aromatase inhibitor combined with recombinant human growth hormone to treat short stature boys with larger bone age can delay bone age progression, improve predicted adult height, and have good safety and tolerability in the short term.
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