细胞膜流动性与通透性影响肿瘤耐药的研究进展  

Progresses of Cell Membrane Fluidity and Permeability Affecting Drug Resistance in Tumor

作　　者：朱翔 徐杨安泰 袁佳琪 周轶平 

机构地区：[1]昆明医科大学,药学院暨云南省天然药物药理重点实验室,云南 昆明

出　　处：《临床医学进展》2020年第8期1703-1710,共8页Advances in Clinical Medicine

摘　　要：肿瘤耐药的产生是临床治疗失败的主要原因。肿瘤细胞膜中的脂质成分伴随耐药产生而改变,可影响细胞膜的流动性和通透性。改变细胞膜流动性和通透性可以实现逆转耐药。本文将对细胞膜流动性与通透性影响肿瘤耐药的研究现状及其检测方法进行综述。The emergence of drug resistance in tumor results in clinical treatment failure. The components of lipids in tumor cell membrane are changed with the development of drug resistance, which modulates fluidity and permeability of the cell membrane. Affecting fluidity and permeability of the cell membrane can be one of the methods to reverse drug resistance in tumor. This article will review recent progress of cell membrane fluidity and permeability affecting drug resistance, and useful techniques for their measurement.

关 键 词：肿瘤 耐药 细胞膜 流动性 通透性 

分 类 号：R73[医药卫生—肿瘤]