抗癫痫药物与骨代谢的相关性研究的进展  

Research Progress on the Relationship between Antiepileptic Drugs and Bone Metabolism

作　　者：安文娜 高学军[1] 

机构地区：[1]延安大学附属医院神经内科,陕西 延安

出　　处：《临床医学进展》2020年第8期1827-1832,共6页Advances in Clinical Medicine

摘　　要：癫痫是一种常见的慢性神经系统疾病,目前癫痫治疗仍以药物治疗为主。大多数抗癫痫药物(antiepileptic drugs, AEDs)都有不同程度的不良反应,其中一个主要的问题是AEDs对骨骼健康的影响。约50%服用AEDs的癫痫患者会出现骨骼异常,主要表现在骨代谢及骨密度方面。但早期AEDs对骨代谢的影响较容易被患者及临床医生忽视。本文主要从AEDs对骨代谢影响的早期监测、影响机制及预防治疗等方面进行阐述,为临床上AEDs药物的选择及AEDs相关骨异常患者的预防治疗提供一定的理论依据。Epilepsy is a common chronic nervous system disease. Epilepsy treatment is still based on drug therapy. Most antiepileptic drugs (AEDs) have different degrees of adverse reactions, and one of the main problems is the effect of AEDs on bone health. About 50% of epilepsy patients taking AEDs will have bone abnormalities, mainly in bone metabolism and bone density. However, the effect of early AEDs on bone metabolism is easy to be ignored by patients and clinicians. In this paper, the effects of AEDs on bone metabolism were mainly discussed from the aspects of early monitoring, influence mechanism and prevention and treatment, so as to provide certain theoretical basis for the selection of clinical AEDs drugs and the prevention and treatment of AEDs related bone abnormalities.

关 键 词：抗癫痫药物(AEDs) 骨代谢 骨密度 骨质疏松 

分 类 号：R74[医药卫生—神经病学与精神病学]