自噬在食管鳞癌中的研究进展  

Research Progress of Autophagy in Esophageal Squamous Cell Carcinoma

作　　者：张云龙 王振波[1] 

机构地区：[1]滨州医学院附属医院肿瘤科,山东 滨州

出　　处：《临床医学进展》2020年第10期2323-2328,共6页Advances in Clinical Medicine

摘　　要：自噬属于细胞程序性死亡,通过降解入侵的病原体、清除受损的细胞器及多余的脂质,降解的物质重新被机体利用以维持细胞稳态和器官完整性的作用。随着对自噬研究的逐渐深入,发现其与食管鳞癌的发生、发展密切相关,不仅在肿瘤的发生前期起着抑制作用,而且在食管鳞癌的发展中起到了促进作用。近年来发现在食管鳞癌的治疗中,通过对自噬的干预有着明显的效果。本文主要综述了细胞自噬的过程和机制、在食管鳞癌中的作用以及参与食管鳞癌治疗的研究进展。Autophagy is a kind of programmed cell death. By degrading invading pathogens, removing damaged organelles and excess lipids, the degraded substances are reused by the body to maintain cell homeostasis and organ integrity. With the deepening of the study on autophagy, it is found that it is closely related to the occurrence and development of esophageal squamous cell carcinoma, which not only plays an inhibitory role in the early stage of the occurrence of tumors, but also plays a promoting role in the development of esophageal cancer. In recent years, it has been found that the intervention of autophagy has obvious effects on the treatment of esophageal cancer. This paper mainly reviews the process and mechanism of autophagy, its role in esophageal cancer and autophagy’s involvement in the treatment of esophageal cancer.

关 键 词：自噬 食管鳞癌治疗 肿瘤免疫 

分 类 号：R73[医药卫生—肿瘤]