ALK重排型肺癌的临床特征分析  

Analysis of Clinical Features of ALK Rearrangement Lung Cancer

作　　者：杨蕾[1] 张在先 许洁 张传玉[1] 

机构地区：[1]青岛大学附属医院放射科,山东 青岛 [2]莒县人民医院放射科,山东 日照

出　　处：《临床医学进展》2021年第1期1-8,共8页Advances in Clinical Medicine

摘　　要：目的:探讨ALK重排型肺癌的临床特征,为ALK阳性肺癌患者的个体化治疗提供依据。材料及方法:选取2016年11月至2019年3月期间我院收治的104例ALK重排阳性的肺癌患者作为阳性组,另随机选取172例ALK重排阴性的肺癌患者作为阴性组,回顾性分析ALK阳性患者的临床特征,数据采用SPSS 26.0软件进行统计分析。结果:ALK阳性组与ALK阴性组在年龄、吸烟史、病理类型、转移情况和TNM分期方面,差别具有统计学意义(P 0.05)。结论:ALK阳性的NSCLC在年轻、不吸烟、腺癌、III~IV期临床分期患者比例较高;与EGFR突变相比,具有ALK基因重排的NSCLC的患者更年轻、更易表现为腺癌、临床分期晚、易发生转移;与野生型肺癌相比,ALK阳性的NSCLC多表现为年轻、女性、不吸烟、腺癌以及III~IV期临床分期。Objective: To explore the clinical characteristics of ALK rearranged lung cancer, and provide a basis for individualized treatment of ALK-positive lung cancer patients. Materials and Methods: 104 patients with ALK rearrangement-positive lung cancer admitted to our hospital from November 2016 to March 2019 were selected as the positive group, and 172 ALK-negative lung cancer patients were randomly selected as the negative group. The clinical characteristics of ALK-positive patients were analyzed retrospectively, and the data was statistically analyzed using SPSS 26.0 software. Results: The ALK-positive group and the ALK-negative group had statistically significant differences in age, smoking history, pathological type, metastasis and TNM staging (P 0.05). Conclusion: ALK-positive NSCLC has a higher proportion of young, non-smokers, adenocarcinoma, and clinical stage III~IV patients;compared with EGFR mutations, NSCLC patients with ALK gene rearrangement are younger and more likely to develop adenocarcinoma. Compared with wild-type lung cancer, ALK-positive NSCLC is mostly young, female, non-smoker, adenocarcinoma, and stage III~IV clinical stage.

关 键 词：肺肿瘤 ALK融合基因 临床特征 

分 类 号：R73[医药卫生—肿瘤]