地塞米松玻璃体植入剂治疗不同OCT分型RVO继发ME的疗效对比  

Comparison of the Efficacy of Intravitreal Dexamethasone Implant for the Treatment of Macular Edema Secondary to RVO with Different OCT Types

作　　者：邴荣登 姜涛[1] 胥美琦 于志颖 刘鹏辉[1] 

机构地区：[1]青岛大学附属医院眼科,山东 青岛

出　　处：《临床医学进展》2021年第3期1343-1352,共10页Advances in Clinical Medicine

摘　　要：目的:观察地塞米松玻璃体植入剂(Ozurdex)对视网膜静脉阻塞(retinal vein occlusion, RVO)继发黄斑水肿(macular edema, ME)的疗效,对比在不同OCT分型中的疗效并探究RVO患者预后影响因素。方法:回顾性研究。选取2018-6/2019-12于我院诊断为RVO继发ME的31例31眼作为研究对象。根据黄斑中心凹厚度(central macular thickness, CMT)分为:CMT ≤ 600 um组(15眼),CMT 】600 um组(16眼);根据是否存在浆液性视网膜脱离(serous retinal detachment, SRD)分为:SRD组(13眼),非SRD组(18眼)。31眼均行玻璃体腔内Ozurdex植入。观察并对比各组治疗前后各时间点(植入前、植入后14 d、1 mo、2 mo、3 mo、4 mo、5 mo、6 mo)的最佳矫正视力(best corrected visual acuity, BCVA)、CMT、眼压、复发率、不良反应。结果:与植入前比较,植入后14 d至6 mo患者的BCVA提高、CMT下降(P 600 um组(P 600 um组(P 600 um及合并SRD的患者复发率高于CMT ≤ 600 um及不合并SRD者(P 600 um及合并SRD的患者更容易复发。初始ME的轻重以及有无SRD是RVO患者的预后影响因素。Aim: To observe the efficacy of intravitreal dexamethasone implant (Ozurdex) for the treatment of macular edema (ME) secondary to retinal vein occlusion (RVO), compare the efficacy in different OCT types and explore the prognostic factors of RVO patients. Methods: Retrospective Study. A total of 31 cases of ME secondary to RVO diagnosed in our hospital from June 2018 to December 2019 were selected as the research subjects. According to the central macular thickness (CMT), they were divided into two groups: the CMT ≤ 600 um group (15 eyes) and the CMT >600 um group (16 eyes);according to the existence of serous retinal detachment (SRD), the patients were divided into the SRD group (13 eyes) and the non-SRD group (18 eyes). All patients were intravitreally injected with Ozurdex. The best corrected visual acuity (BCVA), CMT, intraocular pressure, recurrence rate and adverse reactions were observed and compared at each time point (before implantation, 14 d, 1, 2, 3, 4, 5 and 6 mo after implantation). Results: Compared with pre-injection, BCVA was increased and CMT was decreased from 14 d to 6 mo after injection (P 600 um group (P 600 um group (P 600 um and SRD were more prone to relapse (P 600 um and SRD were more likely to relapse. The severity of the baseline ME and the presence of SRD are prognostic factors in patients with RVO.

关 键 词：视网膜静脉阻塞 黄斑水肿 地塞米松玻璃体内植入剂 光学相干断层扫描 

分 类 号：R73[医药卫生—肿瘤]