儿童后尿道瓣膜的研究进展  

Advances in the Study of Posterior Urethral Valves in Children

作　　者：杨猛 温晟[1,2] 林涛[1,2] 刘星[1,2] 张德迎[1,2] 刘丰[1,2] 魏光辉[1,2] 石艳 华燚[1,2] 

机构地区：[1]重庆医科大学附属儿童医院泌尿外科,重庆 [2]重庆医科大学附属儿童医院儿科研究所,儿童发育疾病研究教育部重点实验室,国家儿童健康与疾病临床医学研究中心,儿童发育重大疾病国家国际科技合作基地,儿科学重庆市重点实验室,儿童泌尿生殖发育与组织工程重点实验室,重庆

出　　处：《临床医学进展》2021年第4期1665-1671,共7页Advances in Clinical Medicine

摘　　要：背景:后尿道瓣膜是先天性后尿路梗阻的常见原因,临床表现多种多样,早期诊断有助于早期解除尿路解剖性梗阻。但是解除机械尿道后仍有部分患儿可能存在膀胱功能障碍、肾功能继续恶化、反复泌尿系感染等。方法:回顾总结既往后尿道瓣膜的文献,总结该疾病特点。结果:总结了发病机制、分型、病理生理、临床表现及诊断、治疗、结局。结论:充分了解后尿道瓣膜的疾病发展,早期诊断、治疗有助于降低死亡率。解除解剖性尿路梗阻后,应根据尿动力、肾功能等进行个体化随访治疗。Background: Posterior urethral valves are a common cause of congenital posterior urinary tract obstruction with a variety of clinical presentations, and early diagnosis can help to relieve anatomical urinary tract obstruction early. However, some children may still have bladder dysfunction, continued deterioration of renal function, and recurrent urinary tract infections after release of the mechanical urethra. Methods: The literature on posterior urethral valves was reviewed to summarise the characteristics of the disease. Results: The pathogenesis, staging, pathophysiology, clinical presentation and diagnosis, treatment and outcome were summarised. Conclusion: Adequate knowledge of the disease development of the posterior urethral valve, early diagnosis and treatment can help to reduce mortality. After relief of anatomical urinary tract obstruction, follow-up treatment should be individualized according to urodynamic and renal function.

关 键 词：后尿道瓣膜 肾发育不良 膀胱功能障碍 肾功能 

分 类 号：R69[医药卫生—泌尿科学]