CD24在胃癌中的研究新进展  

Research Progress of CD24 in Gastric Cancer

作　　者：马文霞 马臻棋 王学红 李惠 杨丽萍 

机构地区：[1]青海大学,青海 西宁 [2]青海大学附属医院消化内科,青海 西宁

出　　处：《临床医学进展》2021年第6期2678-2684,共7页Advances in Clinical Medicine

摘　　要：胃癌(gastric cancer, GC)作为一种分子和表型高度异质性的疾病,是造成人类肿瘤相关死亡的重要因素,严重威胁人类生命健康,但目前对于GC仍缺乏有效的诊疗手段。近年来,肿瘤干细胞(cancer stem cell, CSC)研究备受关注,CD24作为肿瘤干细胞常见的表面标志物,在GC患者组织中呈过量表达,且与肿瘤的发生、发展密切相关。本文就近年来CD24在GC中的表达、作用机制及临床意义相关研究进展作一综述,以期为肿瘤的二级预防提供理论基础。Gastric cancer (GC), as a disease with high molecular and phenotypic heterogeneity, is the third major cause of tumor-related death in humans and poses a serious threat to human life and health. However, there is still a lack of effective means of diagnosis and treatment for the early detection, diagnosis and treatment of GC. In recent years, research on cancer stem cell (CSC) has attracted much attention. As a common surface marker of cancer stem cell, CD24 is overexpressed in GC patient tissues, and is closely related to the occurrence and development of tumors. In this paper, the recent research progress of CD24 expression, mechanism and regulatory pathway in GC is reviewed, with a view to providing theoretical basis for secondary prevention of cancer.

关 键 词：胃癌 胃癌干细胞表面标记物 CD24 

分 类 号：R73[医药卫生—肿瘤]