伴纤维蛋白原异常的IgA-λ型多发性骨髓瘤1例并文献复习  

IgA-λ Multiple Myeloma with Abnormal Fibrigon: A Case Report and Literature Review

作　　者：李金玉 杜娟[1] 孙玉娇[1] 颜学申[1] 李广伦[1] 牛文验 崔中光[1] 

机构地区：[1]青岛大学附属医院血液科,山东 青岛

出　　处：《临床医学进展》2021年第7期3113-3116,共4页Advances in Clinical Medicine

摘　　要：多发性骨髓瘤是浆细胞恶性克隆性疾病,临床表现多样,少数患者存在出血倾向,以鼻出血和牙龈出血多见,本例患者为中老年女性,首发鼻出血及皮肤出血,测纤维蛋白原明显减低,骨穿见成熟红细胞呈明显缗钱状排列,原幼浆细胞占ANC 54.5%,免疫球蛋白(血):IgA 87.70 g/L,λ轻链23.70 g/L。诊断:多发性骨髓瘤(IgA-λ型)。Multiple myeloma (MM) is a malignancy of terminally differentiated plasma cells with various clinical manifestations. A few patients have bleeding tendency, especially nosebleeds and gingival bleeding. This patient is a middle-aged and old woman, with epistaxis and skin bleeding as the first manifestations. The fibrinogen is obviously reduced, and the mature red blood cells are obviously arranged in a money-like way after bone penetration. The protoplasmic cells account for 54.5% of ANC, and immunoglobulin (blood): IgA 87.70 g/L, λ 23.70 g/L. Diagnosis: Multiple myeloma (IgA-λ type).

关 键 词：多发性骨髓瘤 IgA-λ型 α链 异常纤维蛋白原血症 出血 

分 类 号：R73[医药卫生—肿瘤]