炎症微环境:肝肿瘤细胞和肝肿瘤干细胞中的问题  

Inflammatory Microenvironment: Problems of Liver Tumor Cells and Liver Cancer Stem Cells

作　　者：熊凌风 区奕猛[1] 

机构地区：[1]广东药科大学附属第一医院肝胆外科,广东 广州

出　　处：《临床医学进展》2021年第10期4591-4603,共13页Advances in Clinical Medicine

摘　　要：持续的炎症会促进和加重恶性肿瘤。原发性肝癌,主要是肝细胞癌(HCC),是炎症相关癌症的一个明显例子。炎症微环境在HCC发生发展的各阶段起着不可忽视的作用,因此,在确定治疗策略时应充分考虑炎症微环境的影响。概述HCC炎症微环境的组成及该环境对肝癌细胞和肝癌肿瘤干细胞影响的关键问题,探讨其在靶向治疗和免疫治疗盛行时代中的机遇和挑战。Persistent inflammation promotes and aggravates malignancy. Primary liver cancer, mainly hepatocellular carcinoma (HCC), is an obvious example of inflammation-related cancers. The role of the inflammatory microenvironment in the development of HCC cannot be ignored at all stages, therefore, the impact of the inflammatory microenvironment is fully considered in determining treatment strategies. This paper summarizes the composition of the inflammatory microenvironment of HCC and the key issues of the impact of this environment on HCC cells and HCC cancer stem cells, and explores its opportunities and challenges in the prevailing era of targeted therapy and immunotherapy.

关 键 词：炎性微环境 肝细胞癌 治疗策略 肝癌干细胞 

分 类 号：R73[医药卫生—肿瘤]