归巢穿膜肽的研究进展  

Research Advances of Homing Penetrating Peptide

作　　者：苏畅 梁秋华[2] 孙琳 

机构地区：[1]济宁医学院临床医学院,山东 济宁 [2]济宁医学院附属医院内分泌科,山东 济宁 [3]济宁市第一人民医院内分泌科,山东 济宁

出　　处：《临床医学进展》2021年第11期4919-4925,共7页Advances in Clinical Medicine

摘　　要：归巢肽是伴随噬菌体展示技术的发展而被证实具有归巢作用的多肽,它能特异性地识别和结合一些受体或标志物。研究表明,部分归巢肽还具有穿膜特性,能够使蛋白质、RNA、DNA等生物大分子特异性进入到细胞或者组织内发挥作用,在临床诊断和治疗中具有高效性、特异性等优势。本文简要综述对归巢穿膜肽的概述、筛选、分类以及在临床诊断及治疗应用中所获得的研究进展。Homing peptide is a polypeptide that has been confirmed to have a homing effect with the development of phage display technology. It can specifically recognize and bind to some receptors or markers. Studies have shown that some homing peptides also have membrane-penetrating properties, allowing biological macromolecules such as protein, RNA, DNA, etc. to specifically enter cells or tissues to play a role, and have the advantages of high efficiency and specificity in clinical diagnosis and treatment. This article briefly reviews the overview, screening, classification of homing penetrating peptide and the research progress obtained in clinical diagnosis and therapeutic applications.

关 键 词：噬菌体展示技术 归巢穿膜肽 靶向治疗 临床应用 

分 类 号：R73[医药卫生—肿瘤]