建立肺腺癌肝移植瘤模型的相关研究  

Study on Establishing Liver Transplantation Tumor Model of Lung Adenocarcinoma

作　　者：高艳青 王宇飞[2] 吴永坤 郭占林[2] 

机构地区：[1]内蒙古医科大学,内蒙古 呼和浩特 [2]内蒙古医科大学胸外科,内蒙古 呼和浩特

出　　处：《临床医学进展》2022年第3期2051-2055,共5页Advances in Clinical Medicine

摘　　要：肺癌是全世界范围内最常见的恶性肿瘤之一,严重威胁着人类的身心健康。肺癌组织类型有:鳞状细胞癌、腺癌、大细胞癌、小细胞癌等。最常见组织学类型是NSCLC (非小细胞肺癌),而腺癌是最常见的NSCLC类型。腺癌更多是通过血行转移到肝、脑、骨、肾上腺等部位,其中约有20%的NSCLC患者会发生肝转移。在发生单器官转移的肺癌患者中,肝转移患者的生存预后最差,对化疗和靶向治疗抵抗最重,中位生存时间仅3~6个月。目前肿瘤组织穿刺活检的病理结果仍然是诊断的“金标准”,但由于是有创检查,风险较高、患者畏惧、不能耐受等原因,使诊断变得困难。B超(B型超声断面显像仪)、CT (电子计算机断层扫描)、MRI (磁共振检测)等影像学检查虽然可以很好地观察到肿瘤的解剖结构,但由于肿瘤早期缺乏典型的影像学表现使诊断变得困难。PET (正电子发射型计算机断层显像)是一种可以在活体上显示生物分子代谢、受体及神经介质活动的新型影像技术,结合CT、MRI等检测方法很好地显示肿瘤代谢水平及解剖结构,在肿瘤的诊断与鉴别中得到广泛认可。肝移植瘤的治疗包括:介入栓塞、射频消融、化学治疗或靶向治疗等综合治疗。下面将结合肺腺癌肝转移模型的建立,对肝脏移植瘤的诊断及治疗等方面问题作一简单的综述。Lung cancer is one of the most common malignant tumors in the world, a serious threat to human physical and mental health. Lung cancer tissue types include squamous cell carcinoma, adenocar-cinoma, large cell carcinoma, small cell carcinoma and so on. The most common histological type is non-small cell lung cancer (NSCLC), while adenocarcinoma is the most common type of NSCLC. Adenocarcinoma is mostly metastasized to liver, brain, bone, adrenal gland and other sites through hematogenesis, and about 20% of NSCLC patients will have liver metastasis. Among lung cancer patients with single-organ metastasis, patients with liver metastasis have the worst survival prognosis and are most resistant to chemotherapy and targeted therapy, with a median survival time of only 3~6 months. At present, the pathological result of tumor tissue biopsy is still the “gold standard” for diagnosis, but it is difficult to diagnose due to invasive examination, high risk, patient fear, intolerance and other reasons. Imaging examinations such as B-ultrasound, CT and MRI can well observe the anatomical structure of tumors, but the lack of typical imaging manifestations of early tumors makes diagnosis difficult. PET is a new imaging technology that can display biomolecular metabolism, receptor and neurotransmitter activity in vivo. Combined with CT, MRI and other detection methods, PET can well display tumor metabolism level and anatomical structure, and has been widely recognized in tumor diagnosis and differentiation. The treatment of liver transplantation tumor includes interventional embolization, radiofrequency ablation, chemotherapy or targeted therapy. Based on the establishment of liver metastasis model of lung adenocarcinoma, the diagnosis and treatment of liver transplantation tumors are briefly reviewed.

关 键 词：肝移植瘤模型 PET检查 综合治疗 

分 类 号：R735.7[医药卫生—肿瘤]