进展期胃癌转移现状及相关分子机制研究进展  

Current Status of Multiple Metastases in Advanced Gastric Cancer and Research Progress of Related Molecular Mechanisms

作　　者：刘韬 王成[1] 

机构地区：[1]青海大学附属医院胃肠外科,青海 西宁

出　　处：《临床医学进展》2022年第3期2218-2225,共8页Advances in Clinical Medicine

摘　　要：胃癌是常见的消化道恶性肿瘤之一,同时也是因肿瘤致死亡的主要原因之一,死亡率位居第二。因胃癌早期患者症状多为隐匿,无明显临床表现,大多数患者对该疾病的认识不清,故临床上诊断胃癌时多为进展期,且多伴有其他重要脏器(肝、骨、脑等)及血管的转移,从而导致胃癌的手术难度明显加大,术后效果欠佳,预后差、病死率高、生存率低。然而目前,胃癌多脏器转移的相关文献较少,且涉及的相关机制尚不明确,故本文通过搜集相关文献对进展期胃癌发生多脏器(肝、骨、脑)及血管转移及涉及相关机制进行归纳,旨在为临床上诊治进展期胃癌提供参考。Gastric cancer is one of the common malignant tumors of the digestive tract, and it is also one of the main causes of death due to tumors. The death rate of gastric cancer ranks second. Because the symptoms of early gastric cancer patients are insidious mostly, and there is no obvious clinical appearance, most patients have unclear understanding of the disease. Therefore, the clinical diagnosis of gastric cancer is advanced mostly, and it is often accompanied by other important organs (liver, bone, brain, etc.), resulting in significantly increased difficulty in gastric cancer surgery, poor postoperative results, poor prognosis, high mortality, and low survival rate. However, at present, there are few related literatures on multi-organ metastasis of gastric cancer, and the related mechanisms are not clear. Therefore, this article collects related literatures on the occurrence of multi-organ (liver, bone, brain) metastasis and related mechanisms in advanced gastric cancer. In summary, it aims to provide a reference for the clinical diagnosis and treatment of advanced gastric cancer.

关 键 词：胃癌 脏器转移 血管转移 预后 

分 类 号：R735.2[医药卫生—肿瘤]